Fig. 1
From: BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease
Association of BMI rs17415557 with CSF Aβ1-42 levels and rates of cognitive decline. A Participants with minor alleles (G) of rs17415557 have higher CSF Aβ1-42 levels, compared to those with no minor alleles (β (SE) = 0.05(0.02), p = 0.001). Participants with minor alleles of BMI1 rs17415557 had slower cognitive decline over time compared to those with no minor alleles; for B, ADAS-cog13 (a higher score indicating poor cognitive function) in ADNI, β (SE) = − 0.035 (0.016) and p = 0.024; for C, a global composite measure of cognitive function (a lower score indicating poor cognitive function) in ROS/MAP, β (SE) = 0.024 (0.010) and p = 0.020