|
Age (y), median [IQR]
|
76 [72–80]
|
75 [72–78]
|
75 [72–78]
|
74 [72–78]
|
< 0.001
|
0.033
|
|
Female, N (%)
|
252 (70.8)
|
810 (63.8)
|
273 (61.2)
|
508 (65.3)
|
0.014
|
0.152
|
|
Level of education,a N (%)
| | | | |
< 0.001
|
0.540
|
|
Low
|
99 (28.5)
|
247 (19.8)
|
93 (21.3)
|
144 (18.8)
| | |
|
Intermediate
|
126 (36.3)
|
426 (34.1)
|
143 (32.7)
|
266 (34.6)
| | |
|
High
|
122 (35.2)
|
577 (46.2)
|
201 (46.0)
|
358 (46.6)
| | |
|
Household monthly income, N (%)
| | | | |
< 0.001
|
0.108
|
|
< 1000€
|
44 (14.3)
|
79 (6.7)
|
36 (9.0)
|
38 (5.2)
| | |
|
1000–1999€
|
116 (37.7)
|
405 (34.6)
|
140 (35.0)
|
252 (34.4)
| | |
|
2000–2999€
|
84 (27.3)
|
346 (29.5)
|
107 (26.8)
|
226 (30.8)
| | |
|
3000–3999€
|
40 (13.0)
|
202 (17.3)
|
67 (16.8)
|
131 (17.9)
| | |
|
> 4000€
|
24 (7.8)
|
139 (11.9)
|
50 (12.5)
|
86 (11.7)
| | |
|
Marital status, N (%)
| | | | |
0.034
|
0.567
|
|
Single
|
35 (10.0)
|
72 (5.7)
|
21 (4.8)
|
46 (6.0)
| | |
|
Marriedb
|
179 (51.1)
|
703 (56.0)
|
242 (54.9)
|
439 (57.0)
| | |
|
Widowed
|
92 (26.3)
|
325 (25.9)
|
118 (26.8)
|
195 (25.3)
| | |
|
Separated
|
44 (12.6)
|
156 (12.4)
|
60 (13.6)
|
90 (11.7)
| | |
|
Living alone, N (%)
|
149 (42.8)
|
495 (39.6)
|
176 (40.3)
|
301 (39.2)
|
0.284
|
0.712
|
|
Current working status, N (%)
| | | | |
0.367
|
0.615
|
|
Full/part-time paid work
|
6 (1.7)
|
37 (2.9)
|
12 (2.8)
|
24 (3.1)
| | |
|
Retired
|
323 (92.8)
|
1164 (92.5)
|
409 (93.6)
|
714 (92.1)
| | |
|
Never worked
|
19 (5.5)
|
57 (4.5)
|
16 (3.7)
|
37 (4.8)
| | |
|
Town popn. size > 200 000, N (%)
|
243 (67.5)
|
793 (62.4)
|
297 (66.6)
|
465 (59.8)
|
0.078
|
0.018
|
|
First source of information about trial, N (%)
| | | | |
< 0.001
|
0.018
|
|
Doctor
|
157 (44.7)
|
349 (27.7)
|
135 (30.8)
|
199 (25.7)
| | |
|
Media
|
72 (20.5)
|
437 (34.7)
|
132 (30.1)
|
293 (37.9)
| | |
|
Intermediary c
|
122 (34.8)
|
472 (37.5)
|
172 (39.2)
|
282 (36.4)
| | |
|
Family history of AD or related diseases,d N (%)
| | | | |
0.006
|
0.872
|
|
No
|
213 (64.5)
|
691 (56.7)
|
237 (55.9)
|
429 (57.3)
| | |
|
Yes
|
75 (22.7)
|
378 (31.7)
|
136 (32.1)
|
236 (31.5)
| | |
|
Do not know
|
42 (12.7)
|
141 (11.6)
|
51 (12.0)
|
84 (11.2)
| | |
|
Subjective memory complaint, N (%)
| | | | |
0.232
|
0.565
|
|
No
|
68 (20.2)
|
203 (16.7)
|
77 (18.1)
|
122 (16.2)
| | |
|
Yes
|
236 (70.0)
|
909 (74.6)
|
309 (72.7)
|
568 (75.5)
| | |
|
Do not know
|
33 (9.8)
|
107 (8.8)
|
39 (9.2)
|
62 (8.2)
| | |
|
Reporting of memory complaint, N (%)
| | | | |
0.054
|
0.719
|
|
Only to doctor
|
61 (17.9)
|
198 (16.0)
|
72 (16.8)
|
118 (15.5)
| | |
|
Only to friends/family
|
62 (18.2)
|
309 (25.0)
|
101 (23.6)
|
196 (25.7)
| | |
|
To doctor and friends/family
|
82 (24.0)
|
297 (24.0)
|
98 (22.9)
|
185 (24.3)
| | |
|
To no one/no memory complaint
|
136 (39.9)
|
432 (35.0)
|
157 (36.7)
|
264 (34.6)
| | |
|
Impact of memory problems on everyday life, N (%)
| | | | |
0.245
|
0.057
|
|
It bothers me a lot
|
11 (3.2)
|
55 (4.5)
|
28 (6.5)
|
23 (3.0)
| | |
|
It bothers me a little
|
122 (35.5)
|
430 (34.8)
|
137 (32.0)
|
271 (35.7)
| | |
|
It does not really bother me
|
119 (34.6)
|
460 (37.3)
|
161 (37.6)
|
287 (37.8)
| | |
|
It does not bother me at all
|
59 (17.2)
|
210 (17.0)
|
75 (17.5)
|
127 (16.7)
| | |
|
I do not have any memory problems
|
33 (9.6)
|
79 (6.4)
|
27 (6.3)
|
52 (6.8)
| | |
|
Memory problem pointed out by friends/family, N (%)
| | | | |
0.549
|
0.168
|
|
Yes, very often
|
14 (4.7)
|
70 (6.3)
|
32 (8.4)
|
36 (5.3)
| | |
|
Yes, sometimes
|
115 (39)
|
395 (35.7)
|
131 (34.4)
|
245 (35.9)
| | |
|
Yes, rarely
|
83 (28.1)
|
337 (30.5)
|
120 (31.5)
|
204 (29.9)
| | |
|
No
|
83 (28.1)
|
304 (27.5)
|
98 (25.7)
|
198 (29.0)
| | |
|
Memory problems considered to be a risk, N (%)
| | | | |
0.008
|
0.103
|
|
Yes, it is a very big risk for developing diseases
|
66 (20.1)
|
324 (26.6)
|
126 (30.1)
|
190 (25.1)
| | |
|
Yes, it could be a risk
|
205 (62.3)
|
753 (61.8)
|
238 (56.8)
|
485 (64.2)
| | |
|
No, it is not a major risk
|
48 (14.6)
|
114 (9.4)
|
44 (10.5)
|
64 (8.5)
| | |
|
No, it is not a risk at all
|
10 (3.0)
|
28 (2.3)
|
11 (2.6)
|
17 (2.3)
| | |
|
Perceived risk of Alzheimer’s disease,e median [IQR]
|
3.0 [2.8–3.5]
|
3.3 [2.8–3.5]
|
3.3 [2.9–3.8]
|
3.3 [2.8–3.5]
|
0.001
|
0.003
|
|
Perceived social support,e median [IQR]
|
3.5 [2.8–4.0]
|
3.3 [2.8–4.0]
|
3.3 [2.8–3.8]
|
3.3 [3.0–4.0]
|
0.332
|
0.002
|
|
Emotional stability,e mean (SD)
|
2.5 (0.6)
|
2.4 (0.6)
|
2.5 (0.6)
|
2.4 (0.6)
|
0.012
|
0.009
|
|
Internal locus of control,e mean (SD)
|
2.7 (0.5)
|
2.8 (0.4)
|
2.8 (0.4)
|
2.8 (0.4)
|
0.123
|
0.483
|
|
External locus of control (chance),e mean (SD)
|
2.4 (0.7)
|
2.4 (0.6)
|
2.4 (0.6)
|
2.4 (0.6)
|
0.585
|
0.136
|
|
External locus of control (powerful others),e mean (SD)
|
2.7 (0.6)
|
2.7 (0.5)
|
2.7 (0.5)
|
0.7 (0.5)
|
0.438
|
0.561
|
|
CDR 0.5, N (%)
|
N/A
|
499 (40.8)
|
191 (42.8)
|
308 (39.6)
|
N/A
|
0.275
|
|
APO4 ɛ4, N (%)
|
N/A
|
230 (23.6)
|
66 (22.8)
|
164 (23.9)
|
N/A
|
0.728
|
|
Hypercholesterolemia, N (%)
|
N/A
|
352 (29.4)
|
132 (30.1)
|
220 (29.0)
|
N/A
|
0.684
|
|
≥ 1 IADL limitation, N (%)
|
N/A
|
58 (4.9)
|
28 (6.5)
|
30 (4.0)
|
N/A
|
0.055
|
|
≥ 1 Fried frailty criteria, N (%)
|
N/A
|
510 (43.7)
|
208 (48.6)
|
302 (40.8)
|
N/A
|
0.010
|
|
CAIDE dementia risk score ≥ 6, N (%)
|
N/A
|
1026 (86.1)
|
378 (87.5)
|
648 (85.3)
|
N/A
|
0.284
|
|
BMI, N (%)
|
N/A
| | | |
N/A
|
0.041
|
|
18.5–24.9
| |
522 (43.2)
|
169 (38.6)
|
353 (45.8)
| | |
|
25–29.9
| |
503 (41.6)
|
193 (44.1)
|
310 (40.2)
| | |
|
≥ 30
| |
184 (15.2)
|
76 (17.4)
|
108 (14.0)
| | |
|
SBP, median [IQR]
|
N/A
|
140 [130–152]
|
140 [130–153]
|
140 [130–151]
|
N/A
|
0.492
|
|
DBP, mean (SD)
|
N/A
|
79.3 (11.1)
|
79.3 (11.3)
|
79.3 (11.1)
|
N/A
|
0.986
|
|
Cognitive composite score, mean (SD)
|
N/A
|
0.07 (0.65)
|
− 0.04 (0.69)
|
0.13 (0.61)
|
N/A
|
< 0.001
|
|
Depressive symptoms (GDS score), median [IQR]
|
N/A
|
3 [1–4]
|
3 [2–5]
|
2 [1–4]
|
N/A
|
< 0.001
|
|
Subjective memory function, mean (SD)
|
N/A
|
49.8 (16.8)
|
50.8 (17.2)
|
49.3 (16.5)
|
N/A
|
0.130
|
