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Table 3 Scores of ADAS-Cog, S-IADL, MMSE, and NPI at each time point

From: Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase I clinical trial

` ADAS-Cog S-IADL MMSE NPI
Low dose High dose Total Low dose High dose Total Low dose High dose Total Low dose High dose Total
  n = 3 n = 6 n = 9 n = 3 n = 6 n = 9 n = 3 n = 6 n = 9 n = 3 n = 6 n = 9
Screening Mean ± SD 15.0 ± 2.0 22.5 ± 6.2 20.0 ± 6.3 9.3 ± 4.0 13.0 ± 5.8 11.8 ± 5.3 24.0 ± 1.7 21.3 ± 2.7 22.2 ± 2.6 10.0 ± 7.8 1.5 ± 1.5 4.3 ± 5.9
Median 15 23 19.7 10 14.7 13 24 20.7 22 6 1.3 2.7
Min–Max 13–17 12–30 12–30 5–13 5–20 5–20 22–25 18–25 18–25 5–19 0–4 0–19
Baseline Mean ± SD 18.0 ± 1.7 22.8 ± 6.5 21.2 ± 5.8 8.3 ± 4.6 15.3 ± 5.9 13.0 ± 6.3 24.0 ± 2.6 19.7 ± 4.0 21.1 ± 4.1 1.0 ± 1.7 5.3 ± 8.9 3.9 ± 7.4
Median 18 23.5 19.5 8.3 17.5 13 25 19.5 21.8 1 1.5 1
Min–Max 16–19 13–29 13–29 3–11 7–21 3–21 21–26 14–24 14–26 0–3 0–23 0–23
Week 4 Mean ± SD 17.3 ± 3.8 22.2 ± 5.5 20.6 ± 5.3 12.3 ± 5.9 16.5 ± 9.4 15.1 ± 8.2 24.3 ± 1.5 21.5 ± 3.3 22.4 ± 3.1 5.7 ± 2.3 3.5 ± 3.6 4.2 ± 3.2
Median 19 21.3 19.3 10 15.5 12 24 21.5 23.3 5.7 3 4
Min–Max 13–20 16–29 13–29 8–19 5–28 5–28 23–26 17–25 17–26 3–7 0–9 0–9
Week 8 Mean ± SD 15.7 ± 6.1 23.2 ± 6.7 20.7 ± 7.2 10.3 ± 2.1 17.8 ± 6.3 15.3 ± 6.3 26.0 ± 2.0 21.5 ± 3.6 23.0 ± 3.7 5.0 ± 5.6 5.3 ± 6.7 5.2 ± 6.0
Median 17 24 20.3 11 17.5 13 26 22 23.5 4 4 4
Min–Max 9–21 13–31 9–31 8–12 10–28 8–28 24–28 16–26 16–28 0–11 0–18 0–18
Week 12 Mean ± SD 18.7 ± 2.5 25.2 ± 8.2 23.0 ± 7.4 10.3 ± 5.0 16.8 ± 6.5 14.7 ± 6.6 24.0 ± 4.4 20.3 ± 3.6 21.6 ± 4.0 2.3 ± 2.1 3.7 ± 6.0 3.2 ± 4.9
Median 19 23.5 21 11 17 14 26 20 21 3 3.2 2
Min–Max 16–21 17–36 16–36 5–15 8–26 5–26 19–27 16–25 16–27 0–4 0–14 0–14
Mean change from baseline to week 12 Mean ± SD 0.7 ± 4.0 2.3 ± 5.0 1.8 ± 4.5 2.0 ± 2.0 1.5 ± 3.0 1.7 ± 2.6 0.0 ± 2.0 0.7 ± 1.6 0.4 ± 1.7 1.3 ± 2.3 − 1.7 ± 5.8 − 0.7 ± 5.0
Median 0 3.5 3 2 1.5 1.7 0 0.5 0.3 1.3 − 1.5 − 0.5
Min–Max − 3–5 − 4–9 − 4–9 0–4 − 3–6 − 3–6 − 2–2 − 1–3 − 2–3 0–4 − 9–8 − 9–8
Week 52   n = 1 n = 5 n = 6 n = 1 n = 5 n = 6 n = 1 n = 5 n = 6 n = 1 n = 5 n = 6
Mean ± SD 19 30.0 ± 9.8 28.2 ± 9.8 17 23.4 ± 9.0 22.3 ± 8.4 23 16.0 ± 6.0 17.2 ± 6.0 41 2.6 ± 2.1 9.0 ± 15.8
Median 19 31.0 28.5 17 21 19.5 23 17.0 18.5 41 3.0 3.5
Min–Max   16–42 16–42   14–37 14–37   6–21 6–23   0–5 0–41
Week 104   n = 0 n = 4 n = 4 n = 0 n = 4 n = 4 n = 0 n = 4 n = 4 n = 0 n = 4 n = 4
Mean ± SD   35.3 ± 13.6 35.3 ± 13.6   30.0 ± 9.2 30.0 ± 9.2   13.3 ± 8.0 13.3 ± 8.0   0.8 ± 1.0 0.8 ± 1.0
Median   32 32   31 31   14 14   0.7 0.7
Min–Max   23–54 23–54   18–40 18–40   3–22 3–22   0–2 0–2
  1. ADAS-Cog, Alzheimer’s Disease Assessment Scale-Cognitive Subscale; S-IADL, Seoul Instrumental Activities of Daily Living; MMSE, Mini-Mental State Examination; NPI, neuropsychiatric inventory; hUCB-MSC, human umbilical cord blood–derived mesenchymal stem cell; SD, standard deviation