Table 3 Scores of ADAS-Cog, S-IADL, MMSE, and NPI at each time point

n = 3

n = 6

n = 9

n = 3

n = 6

n = 9

n = 3

n = 6

n = 9

n = 3

n = 6

n = 9

Screening

Mean ± SD

15.0 ± 2.0

22.5 ± 6.2

20.0 ± 6.3

9.3 ± 4.0

13.0 ± 5.8

11.8 ± 5.3

24.0 ± 1.7

21.3 ± 2.7

22.2 ± 2.6

10.0 ± 7.8

1.5 ± 1.5

4.3 ± 5.9

Median

15

23

19.7

10

14.7

13

24

20.7

22

6

1.3

2.7

Min–Max

13–17

12–30

12–30

5–13

5–20

5–20

22–25

18–25

18–25

5–19

0–4

0–19

Baseline

Mean ± SD

18.0 ± 1.7

22.8 ± 6.5

21.2 ± 5.8

8.3 ± 4.6

15.3 ± 5.9

13.0 ± 6.3

24.0 ± 2.6

19.7 ± 4.0

21.1 ± 4.1

1.0 ± 1.7

5.3 ± 8.9

3.9 ± 7.4

Median

18

23.5

19.5

8.3

17.5

13

25

19.5

21.8

1

1.5

1

Min–Max

16–19

13–29

13–29

3–11

7–21

3–21

21–26

14–24

14–26

0–3

0–23

0–23

Week 4

Mean ± SD

17.3 ± 3.8

22.2 ± 5.5

20.6 ± 5.3

12.3 ± 5.9

16.5 ± 9.4

15.1 ± 8.2

24.3 ± 1.5

21.5 ± 3.3

22.4 ± 3.1

5.7 ± 2.3

3.5 ± 3.6

4.2 ± 3.2

Median

19

21.3

19.3

10

15.5

12

24

21.5

23.3

5.7

3

4

Min–Max

13–20

16–29

13–29

8–19

5–28

5–28

23–26

17–25

17–26

3–7

0–9

0–9

Week 8

Mean ± SD

15.7 ± 6.1

23.2 ± 6.7

20.7 ± 7.2

10.3 ± 2.1

17.8 ± 6.3

15.3 ± 6.3

26.0 ± 2.0

21.5 ± 3.6

23.0 ± 3.7

5.0 ± 5.6

5.3 ± 6.7

5.2 ± 6.0

Median

17

24

20.3

11

17.5

13

26

22

23.5

4

4

4

Min–Max

9–21

13–31

9–31

8–12

10–28

8–28

24–28

16–26

16–28

0–11

0–18

0–18

Week 12

Mean ± SD

18.7 ± 2.5

25.2 ± 8.2

23.0 ± 7.4

10.3 ± 5.0

16.8 ± 6.5

14.7 ± 6.6

24.0 ± 4.4

20.3 ± 3.6

21.6 ± 4.0

2.3 ± 2.1

3.7 ± 6.0

3.2 ± 4.9

Median

19

23.5

21

11

17

14

26

20

21

3

3.2

2

Min–Max

16–21

17–36

16–36

5–15

8–26

5–26

19–27

16–25

16–27

0–4

0–14

0–14

Mean change from baseline to week 12

Mean ± SD

0.7 ± 4.0

2.3 ± 5.0

1.8 ± 4.5

2.0 ± 2.0

1.5 ± 3.0

1.7 ± 2.6

0.0 ± 2.0

0.7 ± 1.6

0.4 ± 1.7

1.3 ± 2.3

− 1.7 ± 5.8

− 0.7 ± 5.0

Median

0

3.5

3

2

1.5

1.7

0

0.5

0.3

1.3

− 1.5

− 0.5

Min–Max

− 3–5

− 4–9

− 4–9

0–4

− 3–6

− 3–6

− 2–2

− 1–3

− 2–3

0–4

− 9–8

− 9–8

Week 52

n = 1

n = 5

n = 6

n = 1

n = 5

n = 6

n = 1

n = 5

n = 6

n = 1

n = 5

n = 6

Mean ± SD

19

30.0 ± 9.8

28.2 ± 9.8

17

23.4 ± 9.0

22.3 ± 8.4

23

16.0 ± 6.0

17.2 ± 6.0

41

2.6 ± 2.1

9.0 ± 15.8

Median

19

31.0

28.5

17

21

19.5

23

17.0

18.5

41

3.0

3.5

Min–Max

16–42

16–42

14–37

14–37

6–21

6–23

0–5

0–41

Week 104

n = 0

n = 4

n = 4

n = 0

n = 4

n = 4

n = 0

n = 4

n = 4

n = 0

n = 4

n = 4

Mean ± SD

35.3 ± 13.6

35.3 ± 13.6

30.0 ± 9.2

30.0 ± 9.2

13.3 ± 8.0

13.3 ± 8.0

0.8 ± 1.0

0.8 ± 1.0

Median

32

32

31

31

14

14

0.7

0.7

Min–Max

23–54

23–54

18–40

18–40

3–22

3–22

0–2

0–2