Fig. 7
![Fig. 7](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13195-021-00890-9/MediaObjects/13195_2021_890_Fig7_HTML.png)
Increased tau pathology in HFD-treated 3 × Tg mice. a Representative immunohistochemical images of tau hyperphosphorylation (p-S396) in different hippocampal subregions (CA1, CA3, and DG). Scale bar, 200 μm (overall pictures) and 50 μm (enlarged pictures in the lower right corner of the overall pictures), respectively. b Western blotting results of Tau and p-Tau in the brain tissues of different-treated 3 × Tg mice. c The relative quantity of p-Tau proteins is normalized to that of Tau and expressed as mean ± SD (n = 4), unpaired Student t test, two-tailed. ***p < 0.001