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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer’s disease associated with chronic platelet activation

Fig. 7

Increased tau pathology in HFD-treated 3 × Tg mice. a Representative immunohistochemical images of tau hyperphosphorylation (p-S396) in different hippocampal subregions (CA1, CA3, and DG). Scale bar, 200 μm (overall pictures) and 50 μm (enlarged pictures in the lower right corner of the overall pictures), respectively. b Western blotting results of Tau and p-Tau in the brain tissues of different-treated 3 × Tg mice. c The relative quantity of p-Tau proteins is normalized to that of Tau and expressed as mean ± SD (n = 4), unpaired Student t test, two-tailed. ***p < 0.001

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Alzheimer's Research & Therapy

ISSN: 1758-9193