Table 3 Distribution of participant characteristics and their association with Aβ misfolding and clinical Alzheimer’s disease
From: Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood
Aβ misfolding | clinical Alzheimer’s disease | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Characteristic at baseline | Ntotal (col %) | NAbeta+ (row %) | OR (95% CI) | p-valueb | Ntotal (col %) | NAD (row %) | OR (95% CI) | p-valueb | |
Adjusteda | Adjustedc | ||||||||
Diabetes | No | 686 (78.7) | 100 (14.6) | Ref. | 5066 (85.6) | 116 (2.3) | Ref. | ||
Yes | 186 (21.3) | 31 (16.7) | 1.02 (0.59–1.77) | .9357 | 855 (14.4) | 30 (3.5) | 1.10 (0.65–1.87) | .7144 | |
Physical activity | Inactive | 278 (31.9) | 35 (12.6) | Ref. | 1110 (18.6) | 49 (4.4) | Ref. | ||
Low | 420 (48.2) | 68 (16.2) | 1.44 (0.82–2.53) | .2088 | 2705 (45.3) | 57 (2.1) | 0.57 (0.39–0.85) | .0056 | |
Medium/high | 173 (19.9) | 28 (16.2) | 1.14 (0.58–2.25) | .6978 | 2158 (36.1) | 40 (1.9) | 0.64 (0.41–1.01) | .0548 | |
Smoking | Never | 462 (54.9) | 66 (14.3) | Ref. | 2974 (50.8) | 83 (2.8) | Ref. | ||
Former | 281 (33.4) | 47 (16.7) | 1.07 (0.61–1.87) | .8103 | 1975 (33.7) | 42 (2.1) | 0.89 (0.59–1.35) | .5957 | |
Current | 98 (11.7) | 17 (17.4) | 1.19 (0.57–2.47) | .6452 | 908 (15.5) | 16 (1.8) | 1.07 (0.61–1.86) | .8212 | |
Frailty index | Non-frail 0 to ≤0.20 | 206 (38.8) | 31 (15.1) | Ref. | 2337 (53.0) | 39 (1.7) | Ref. | ||
Pre-frail > 0.20 to < 0.45 | 253 (47.7) | 50 (19.8) | 1.14 (0.68–1.91) | .6132 | 1742 (39.5) | 45 (2.6) | 1.11 (0.71–1.72) | .6468 | |
Frail ≥0.45 | 72 (13.6) | 9 (12.5) | 0.75 (0.35–1.58) | .6452 | 330 (7.5) | 15 (4.6) | 2.02 (1.10–3.95) | .0275 | |