Table 2 Distribution of BMI at different time points and its association with Aβ misfolding and clinical Alzheimer’s disease
From: Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood
Aβ misfolding | Clinical Alzheimer’s disease | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Time point | Ntotal (col %) | NAbeta+ (row %) | OR (95% CI) | p-valueb | Ntotal (col %) | NAD (row %) | HR (95% CI) | p-valueb | |
Adjusteda | Adjustedc | ||||||||
Baseline | < 25 kg/m2 | 208 (24.6) | 37 (17.8) | Ref. | 1657 (28.2) | 45 (2.7) | Ref. | ||
≥25 kg/m2 | 638 (75.4) | 90 (14.1) | 0.82 (0.49–1.36) | .4385 | 4225 (71.8) | 98 (2.3) | 0.66 (0.43–1.00) | .0501 | |
Per 5 kg/m2 | 846 (100) | 127 (15.0) | 0.73 (0.52–1.03) | .0705 | 5882 (100) | 143 (2.4) | 0.88 (0.67–1.16) | .3736 | |
At age 50 | < 25 kg/m2 | 335 (42.8) | 59 (17.6) | Ref. | 2341 (41.3) | 62 (2.7) | Ref. | ||
≥25 kg/m2 | 448 (57.2) | 61 (13.6) | 0.88 (0.54–1.41) | .5817 | 3327 (58.7) | 73 (2.2) | 0.81 (0.54–1.21) | .3048 | |
Per 5 kg/m2 | 783 (100) | 120 (15.3) | 0.64 (0.43–0.96) | .0314 | 5668 (100) | 135 (2.4) | 1.13 (0.83–1.53) | .4455 | |
At age 40 | < 25 kg/m2 | 468 (61.9) | 74 (15.8) | Ref. | 3269 (58.3) | 76 (2.3) | Ref. | ||
≥25 kg/m2 | 288 (38.1) | 38 (13.2) | 0.87 (0.53–1.42) | .5760 | 2340 (41.7) | 49 (2.1) | 1.08 (0.72–1.62) | .7101 | |
Per 5 kg/m2 | 756 (100) | 112 (14.8) | 0.80 (0.54–1.19) | .2704 | 5609 (100) | 125 (2.2) | 1.13 (0.81–1.56) | .4753 | |