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Table 2 Distribution of BMI at different time points and its association with Aβ misfolding and clinical Alzheimer’s disease

From: Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood

  Aβ misfolding Clinical Alzheimer’s disease
Time point Ntotal
(col %)
NAbeta+
(row %)
OR (95% CI) p-valueb Ntotal
(col %)
NAD
(row %)
HR (95% CI) p-valueb
Adjusteda Adjustedc
Baseline < 25 kg/m2 208 (24.6) 37 (17.8) Ref.   1657 (28.2) 45 (2.7) Ref.  
≥25 kg/m2 638 (75.4) 90 (14.1) 0.82 (0.49–1.36) .4385 4225 (71.8) 98 (2.3) 0.66 (0.43–1.00) .0501
Per 5 kg/m2 846 (100) 127 (15.0) 0.73 (0.52–1.03) .0705 5882 (100) 143 (2.4) 0.88 (0.67–1.16) .3736
At age 50 < 25 kg/m2 335 (42.8) 59 (17.6) Ref.   2341 (41.3) 62 (2.7) Ref.  
≥25 kg/m2 448 (57.2) 61 (13.6) 0.88 (0.54–1.41) .5817 3327 (58.7) 73 (2.2) 0.81 (0.54–1.21) .3048
Per 5 kg/m2 783 (100) 120 (15.3) 0.64 (0.43–0.96) .0314 5668 (100) 135 (2.4) 1.13 (0.83–1.53) .4455
At age 40 < 25 kg/m2 468 (61.9) 74 (15.8) Ref.   3269 (58.3) 76 (2.3) Ref.  
≥25 kg/m2 288 (38.1) 38 (13.2) 0.87 (0.53–1.42) .5760 2340 (41.7) 49 (2.1) 1.08 (0.72–1.62) .7101
Per 5 kg/m2 756 (100) 112 (14.8) 0.80 (0.54–1.19) .2704 5609 (100) 125 (2.2) 1.13 (0.81–1.56) .4753
  1. aAdjusted for all variables listed in Table 1 and case/control status
  2. bp-value derived from multiple logistic regression for adjusted odds ratios
  3. cAdjusted for all variables listed in Table 1