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Table 2 Annual changes in cognition across Braak-stages

From: Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals

  Braak0 BraakI+ BraakI–IV+ BraakI–VI+ Braakatypical+ p value
MMSE  − 0.08 (0.27)b, c, d, e  − 0.39 (0.56)a, d  − 0.59 (0.51)a, d  − 1.60 (1.01)a, b, c, e  − 0.55 (0.80)a, d  < 0.001
ADAS13 0.85 (0.48)b, c, d, e 1.30 (0.67)a, c, d 1.80 (0.83)a, b, d 2.55 (0.78)a, b, c, e 1.42 (0.84)a, d  < 0.001
ADNI-MEM 0.02 (0.06)b, c, d  − 0.03 (0.07)a, c, d  − 0.08 (0.08)a, b, d  − 0.14 (0.06)a, b, c, e  − 0.02 (0.07)d  < 0.001
  1. Values are presented as mean (SD). p values were derived from ANOVAs with post hoc Tukey tests
  2. MMSE Mini-Mental State Examination, ADAS13 Alzheimer’s disease assessment scale, cognitive subscale, ADNI-MEM episodic memory composite score
  3. Mean values significantly (p < 0.05) different from aBraak0, bBraakI+, cBraakI–IV+, dBraakI–VI+, eBraakatypical+