Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals

Table 2 Annual changes in cognition across Braak-stages

	Braak⁰	Braak^I+	Braak^I–IV+	Braak^I–VI+	Braak^atypical+	p value
MMSE	− 0.08 (0.27)^{b, c, d, e}	− 0.39 (0.56)^{a, d}	− 0.59 (0.51)^{a, d}	− 1.60 (1.01)^{a, b, c, e}	− 0.55 (0.80)^{a, d}	< 0.001
ADAS13	0.85 (0.48)^{b, c, d, e}	1.30 (0.67)^{a, c, d}	1.80 (0.83)^{a, b, d}	2.55 (0.78)^{a, b, c, e}	1.42 (0.84)^{a, d}	< 0.001
ADNI-MEM	0.02 (0.06)^{b, c, d}	− 0.03 (0.07)^{a, c, d}	− 0.08 (0.08)^{a, b, d}	− 0.14 (0.06)^{a, b, c, e}	− 0.02 (0.07)^d	< 0.001

Values are presented as mean (SD). p values were derived from ANOVAs with post hoc Tukey tests
MMSE Mini-Mental State Examination, ADAS13 Alzheimer’s disease assessment scale, cognitive subscale, ADNI-MEM episodic memory composite score
Mean values significantly (p < 0.05) different from ^aBraak⁰, ^bBraak^I+, ^cBraak^I–IV+, ^dBraak^I–VI+, ^eBraak^atypical+

ISSN: 1758-9193