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Table 3 Baseline and 4-year remote follow-up neurologic, neurocognitive, functional, and health assessments

From: Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project

Domain Test/Instrument Baseline Follow-up
Neurologic exam Semi-structured clinical examination of cranial nerves, sensory functions, muscle strength, fasciculations, and reflexes I
Motor International Parkinson and Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) [101] I V
Timed Up and Go (TUG) [102] I
Effort (symptom validity) Test of Memory Malingering (TOMM) [103] [104] I V
Estimated premorbid intelligence Wide Range Achievement Test-Fourth Edition (WRAT-4) Word Reading [] I
Cognitive screening Montreal Cognitive Assessment (MoCA) [106, 107] I T,V
Attention, visual scanning, and psychomotor speed Symbol Digit Modalities Test [108] I V
Trail Making Test Part A [109] I
Unified Data Set (UDS) Number Span Test [110] I T
Executive function Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) Global Executive Composite (GEC; Participant and Informant) [111] R R
BRIEF-A Metacognition Index (MI; Participant and Informant) [111] R R
Phonemic Fluency - Controlled Oral Word Association Test (COWAT) [112] I T
Golden Stroop Color and Word Interference [98] I
Neuropsychological Assessment Battery (NAB) Mazes [99, 113] I
Trail Making Test Part B [109] I
NAB Categories [99] V
Cambridge Neuropsychological Test Automated Battery (CANTAB) One Touch Stockings of Cambridge (OTS) [114, 115] C
CANTAB Spatial Working Memory (SWW) [114, 115] C
CANTAB Cambridge Gambling Task (CGT) [114, 115] C
Learning and memory Brief Visuospatial Memory Test – Revised (BVMT-R) [104] I V
UDS Craft Story [110] I T
NAB List Learning [99] I T
CANTAB Paired Associate Learning (PAL) [114, 115] C
CANTAB Pattern Recognition Memory (PRM) [114, 115] C
Language Category (Semantic) Fluency - Animals [112, 116] I T
Category (Semantic) Fluency - Vegetables [112, 116] T
UDS Multilingual Naming Test (MINT) [110] I V
Visuospatial ability Judgment of Line Orientation (JOLO) [117] I V
BVMT-R Copy [104] I V
Emotional facial perception CANTAB Emotional Recognition Task (ERT) [114, 115] C
Dementia severity Functional Activities Questionnaire (FAQ; Participant and Informant) [118] R R
Quick Dementia Rating System (QDRS; Participant and Informant) [119] R R
Sleep Mayo Sleep Questionnaire (MSQ; Participant and Informant) [120] R R
Epworth Sleepiness Scale [121] R R
Olfactory Brief Smell Identification Test (B-SIT) [122] I
Pain Headache Impact Test (HIT-6) [123] R R
Brief Pain Inventory (BPI) [124, 125] P P
Substance use Alcohol Use Disorders Identification Test: Interview Version (AUDIT) [126] I T
Modified National Institute on Drug Abuse (NIDA) Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) version 2.0 [127] I T
Health status EQ-5D-5L Health Questionnaire [128] P P
National Health and Nutrition Examination Survey (NHANES) Physical Activity and Physical Fitness Questionnaire (PAQ) [129] I T
NHANES Weight History Questionnaire [130] I T
  1. Note: I administered in-person; V Administered over HIPAA compliant Zoom Video conferencing (modified from original in-person method); T administered over telephone; R administered over REDCap online data capture forms; P administered on paper form; C administered online using CANTAB Web-Based Testing platform