Skip to main content

Table 1 Demographics and the RSMS total, EX and SP scores for each genetic group, split by global CDR® plus NACC FTLD score (0, 0.5, 1+). N represents number of participants, mean (standard deviation) shown for age, education and cognitive test scores. In the symptomatic (1+) groups, MMSE scores were significantly lower in GRN mutation carriers than in the C9orf72 expansion carrier group but no other differences were seen, whilst no differences were seen in the CDR® plus NACC FTLD-SB

From: The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort

  N Sex Age (years) Education (years) MMSE (/30) CDR plus NACC FTLD-SB RSMS total (/65) RSMS EX (/30) RSMS SP (/35)
% male Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD) Mean (SD)
Controls 269 42 46.2 (13.0) 14.4 (3.4) 29.3 (1.1) 0.2 (0.4) 47.8 (8.4) 23.3 (4.2) 24.5 (5.3)
C9orf72 0 93 41 43.9 (11.6) 14.3 (3.0) 29.1 (1.2) 0.0 (0.0) 47.1 (10.5) 22.8 (5.4) 24.3 (6.0)
  0.5 34 44 49.7 (11.2) 14.0 (2.6) 28.4 (2.2) 1.1 (0.7) 41.9 (11.4) 19.8 (6.2) 22.1 (6.3)
1+ 66 65 62.7 (9.5) 13.0 (3.8) 23.3 (6.8) 11.1 (5.6) 23.5 (12.3) 9.6 (7.0) 14.0 (6.6)
GRN 0 122 34 45.6 (12.2) 14.7 (3.5) 29.5 (0.8) 0.0 (0.0) 47.9 (8.9) 23.6 (4.0) 24.3 (5.9)
  0.5 24 46 51.3 (13.8) 14.0 (4.3) 28.6 (2.3) 0.9 (0.8) 43.8 (10.7) 21.6 (6.3) 22.2 (5.6)
1+ 47 47 63.0 (7.4) 11.7 (3.4) 20.1 (7.7) 9.8 (6.2) 28.6 (12.1) 12.9 (6.7) 15.6 (6.1)
MAPT 0 41 41 38.3 (11.0) 14.3 (3.3) 29.5 (0.8) 0.0 (0.0) 50.7 (9.7) 24.0 (4.5) 26.7 (6.0)
  0.5 13 31 46.4 (12.8) 13.6 (2.5) 28.1 (2.3) 1.1 (0.8) 50.1 (14.2) 23.8 (7.5) 26.3 (7.1)
1+ 21 57 58.9 (9.4) 13.6 (4.0) 21.9 (8.1) 10.3 (6.0) 22.8 (18.9) 9.4 (9.5) 13.4 (9.8)