Table 3 Statistically significant DEmiRNAs identified by the meta-analysis
MiRNAs | Comparison ID | Number of upregulated case in AD | Number of downregulated case in AD | Number of control case | Weight | P value | FDR | LogOR | 95% CI | τ^2 | I^2 |
|---|---|---|---|---|---|---|---|---|---|---|---|
miR-107 | 27501295_WB | 172 | 109 | 25.08% | 3.74E−25 | 1.61E−23 | − 10.40 | [− 12.36 , − 8.43] | 0.00 | 0.00% | |
25742200_Pla | 97 | 81 | 25.03% | ||||||||
23895045_WB | 94 | 21 | 24.82% | ||||||||
31420923_Pla | 120 | 120 | 25.07% | ||||||||
miR-106b-3p | 29036818_Ser_Mild | 31 | 86 | 24.98% | 1.05E−20 | 1.53E−19 | 9.38 | [7.41 , 11.35] | 0.00 | 0.00% | |
29036818_Ser_Mod | 52 | 86 | 25.06% | ||||||||
29036818_Ser_Sev | 38 | 86 | 25.01% | ||||||||
28626163_Ser | 45 | 40 | 24.96% | ||||||||
miR-22-3p | 29036818_Ser_Mild | 31 | 86 | 24.98% | 1.07E−20 | 1.53E−19 | − 9.38 | [− 11.34 , − 7.41] | 0.00 | 0.00% | |
29036818_Ser_Mod | 52 | 86 | 25.06% | ||||||||
29036818_Ser_Sev | 38 | 86 | 25.01% | ||||||||
29746584_Ser | 47 | 38 | 24.95% | ||||||||
miR-126-5p | 29036818_Ser_Mild | 31 | 86 | 33.28% | 2.06E−16 | 1.48E−15 | − 9.53 | [− 11.81 , − 7.26] | 0.00 | 0.00% | |
29036818_Ser_Mod | 52 | 86 | 33.39% | ||||||||
29036818_Ser_Sev | 38 | 86 | 33.33% | ||||||||
miR-148b-5p | 29036818_Ser_Mild | 31 | 86 | 33.28% | 2.06E−16 | 1.48E−15 | − 9.53 | [− 11.81 , − 7.26] | 0.00 | 0.00% | |
29036818_Ser_Mod | 52 | 86 | 33.39% | ||||||||
29036818_Ser_Sev | 38 | 86 | 33.33% | ||||||||
miR-181c-3p | 29036818_Ser_Mild | 31 | 86 | 33.28% | 2.06E−16 | 1.48E−15 | − 9.53 | [− 11.81 , − 7.26] | 0.00 | 0.00% | |
29036818_Ser_Mod | 52 | 86 | 33.39% | ||||||||
29036818_Ser_Sev | 38 | 86 | 33.33% | ||||||||
miR-128-3p | 27239545_PBMC | 30 | 30 | 25.02% | 4.64E−16 | 2.85E−15 | 8.19 | [6.21 , 10.17] | 0.00 | 0.00% | |
24064186_PBMC_Mon | 34 | 37 | 25.08% | ||||||||
24064186_PBMC_Lym | 34 | 37 | 25.08% | ||||||||
30328325_Pla | 20 | 20 | 24.82% | ||||||||
miR-93-5p | 26078483_Ser | 79 | 75 | 50.13% | 2.3E−11 | 1.24E−10 | − 9.50 | [− 12.28 , − 6.71] | 0.00 | 0.00% | |
28626163_Ser | 45 | 40 | 49.87% | ||||||||
miR-29c-3p | 25955795_WB | 30 | 30 | 49.88% | 1.81E−09 | 8.65E−09 | − 8.56 | [− 11.36 , − 5.77] | 0.00 | 0.00% | |
28626163_Ser | 45 | 40 | 50.12% | ||||||||
miR-132-3p | 29746584_Ser | 47 | 38 | 50.28% | 6.67E−09 | 2.87E−08 | − 8.27 | [− 11.07 , − 5.48] | 0.00 | 0.00% | |
31849573_Pla | 16 | 31 | 49.72% | ||||||||
miR-222-3p | 28849039_Ser_Mil | 30 | 30 | 50.00% | 8.09E−09 | 3.16E−08 | − 8.22 | [− 11.02 , − 5.43] | 0.00 | 0.00% | |
28849039_Ser_Mod | 30 | 30 | 50.00% | ||||||||
miR-34c-5p | 24550773_Pla | 25 | 27 | 50.00% | 2.67E−08 | 9.58E−08 | 7.94 | [5.14 , 10.74] | 0.00 | 0.00% | |
24550773_PBMC | 25 | 27 | 50.00% | ||||||||
let-7d-5p | 23922807_Pla_C2 | 20 | 17 | 49.74% | 8.9E−06 | 2.73E−05 | − 9.39 | [− 13.54 , − 5.25] | 4.89 | 54.62% | |
24577456_Ser | 158 | 155 | 50.26% | ||||||||
miR-191-5p | 23922807_Pla_C2 | 20 | 17 | 49.74% | 8.9E−06 | 2.73E−05 | − 9.39 | [− 13.54 , − 5.25] | 4.89 | 54.62% | |
24577456_Ser | 158 | 155 | 50.26% | ||||||||
miR-200a-3p | 28179587_Pla_AD2 | 13 | 9 | 50.26% | 3.37E−05 | 8.05E−05 | 6.01 | [3.17 , 8.85] | 0.00 | 0.00% | |
28179587_Pla_MCI-AD2 | 8 | 9 | 49.74% | ||||||||
miR-483-5p | 28179587_Pla_AD2 | 13 | 9 | 50.26% | 3.37E−05 | 8.05E−05 | 6.01 | [3.17 , 8.85] | 0.00 | 0.00% | |
28179587_Pla_MCI-AD2 | 8 | 9 | 49.74% | ||||||||
miR-486-5p | 28179587_Pla_AD2 | 13 | 9 | 50.26% | 3.37E−05 | 8.05E−05 | 6.01 | [3.17 , 8.85] | 0.00 | 0.00% | |
28179587_Pla_MCI-AD2 | 8 | 9 | 49.74% | ||||||||
miR-502-3p | 28179587_Pla_AD2 | 13 | 9 | 50.26% | 3.37E−05 | 8.05E−05 | 6.01 | [3.17 , 8.85] | 0.00 | 0.00% | |
28179587_Pla_MCI-AD2 | 8 | 9 | 49.74% |