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Table 3 Statistically significant DEmiRNAs identified by the meta-analysis

From: Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer’s disease by meta-analysis and adaptive boosting ensemble learning

MiRNAs Comparison ID Number of upregulated case in AD Number of downregulated case in AD Number of control case Weight P value FDR LogOR 95% CI τ^2 I^2
miR-107 27501295_WB   172 109 25.08% 3.74E−25 1.61E−23 − 10.40 [− 12.36 , − 8.43] 0.00 0.00%
25742200_Pla   97 81 25.03%       
23895045_WB   94 21 24.82%       
31420923_Pla   120 120 25.07%       
miR-106b-3p 29036818_Ser_Mild 31   86 24.98% 1.05E−20 1.53E−19 9.38 [7.41 , 11.35] 0.00 0.00%
29036818_Ser_Mod 52   86 25.06%       
29036818_Ser_Sev 38   86 25.01%       
28626163_Ser 45   40 24.96%       
miR-22-3p 29036818_Ser_Mild   31 86 24.98% 1.07E−20 1.53E−19 − 9.38 [− 11.34 , − 7.41] 0.00 0.00%
29036818_Ser_Mod   52 86 25.06%       
29036818_Ser_Sev   38 86 25.01%       
29746584_Ser   47 38 24.95%       
miR-126-5p 29036818_Ser_Mild   31 86 33.28% 2.06E−16 1.48E−15 − 9.53 [− 11.81 , − 7.26] 0.00 0.00%
29036818_Ser_Mod   52 86 33.39%       
29036818_Ser_Sev   38 86 33.33%       
miR-148b-5p 29036818_Ser_Mild   31 86 33.28% 2.06E−16 1.48E−15 − 9.53 [− 11.81 , − 7.26] 0.00 0.00%
29036818_Ser_Mod   52 86 33.39%       
29036818_Ser_Sev   38 86 33.33%       
miR-181c-3p 29036818_Ser_Mild   31 86 33.28% 2.06E−16 1.48E−15 − 9.53 [− 11.81 , − 7.26] 0.00 0.00%
29036818_Ser_Mod   52 86 33.39%       
29036818_Ser_Sev   38 86 33.33%       
miR-128-3p 27239545_PBMC 30   30 25.02% 4.64E−16 2.85E−15 8.19 [6.21 , 10.17] 0.00 0.00%
24064186_PBMC_Mon 34   37 25.08%       
24064186_PBMC_Lym 34   37 25.08%       
30328325_Pla 20   20 24.82%       
miR-93-5p 26078483_Ser   79 75 50.13% 2.3E−11 1.24E−10 − 9.50 [− 12.28 , − 6.71] 0.00 0.00%
28626163_Ser   45 40 49.87%       
miR-29c-3p 25955795_WB   30 30 49.88% 1.81E−09 8.65E−09 − 8.56 [− 11.36 , − 5.77] 0.00 0.00%
28626163_Ser   45 40 50.12%       
miR-132-3p 29746584_Ser   47 38 50.28% 6.67E−09 2.87E−08 − 8.27 [− 11.07 , − 5.48] 0.00 0.00%
31849573_Pla   16 31 49.72%       
miR-222-3p 28849039_Ser_Mil   30 30 50.00% 8.09E−09 3.16E−08 − 8.22 [− 11.02 , − 5.43] 0.00 0.00%
28849039_Ser_Mod   30 30 50.00%       
miR-34c-5p 24550773_Pla 25   27 50.00% 2.67E−08 9.58E−08 7.94 [5.14 , 10.74] 0.00 0.00%
24550773_PBMC 25   27 50.00%       
let-7d-5p 23922807_Pla_C2   20 17 49.74% 8.9E−06 2.73E−05 − 9.39 [− 13.54 , − 5.25] 4.89 54.62%
24577456_Ser   158 155 50.26%       
miR-191-5p 23922807_Pla_C2   20 17 49.74% 8.9E−06 2.73E−05 − 9.39 [− 13.54 , − 5.25] 4.89 54.62%
24577456_Ser   158 155 50.26%       
miR-200a-3p 28179587_Pla_AD2 13   9 50.26% 3.37E−05 8.05E−05 6.01 [3.17 , 8.85] 0.00 0.00%
28179587_Pla_MCI-AD2 8   9 49.74%       
miR-483-5p 28179587_Pla_AD2 13   9 50.26% 3.37E−05 8.05E−05 6.01 [3.17 , 8.85] 0.00 0.00%
28179587_Pla_MCI-AD2 8   9 49.74%       
miR-486-5p 28179587_Pla_AD2 13   9 50.26% 3.37E−05 8.05E−05 6.01 [3.17 , 8.85] 0.00 0.00%
28179587_Pla_MCI-AD2 8   9 49.74%       
miR-502-3p 28179587_Pla_AD2 13   9 50.26% 3.37E−05 8.05E−05 6.01 [3.17 , 8.85] 0.00 0.00%
28179587_Pla_MCI-AD2 8   9 49.74%