Table 2 DEmiRNAs reported by the included differential miRNA expression studies. The bold DEmiRNAs were reported by at least two independent comparisons and were qualified for the subsequent meta-analysis

31857133_Ser

miR-193a-3p

Down

< 0.001

31811079_Ser

miR-346

Up

0.0013

miR-345-5p

Up

0.0239

miR-122-3p

Up

0.0001

miR-1291

Up

0.0052

miR-640

Up

0.0004

miR-650

Up

0.0035

miR-1285-3p

Up

0.0032

miR-1299

Up

0.0003

miR-1267

Up

0.0055

miR-208b-3p

Down

0.0006

miR-206

Down

0.0004

31849573_Pla

miR-132-3p

Down

0.0333

miR-212-3p

Down

0.001

31809862_WB

miR-532-5p

Up

4.8 × 10E−30

miR-1468-5p

Down

6.2 × 10E−12

31766231_Pla

miR-206

Up

< 0.025

31691877_Ser

miR-22-5p

Up

≤ 0.005

miR-23a-3p

Up

≤ 0.05

miR-29a-3p

Up

≤ 0.05

miR-125b-5p

Up

≤ 0.005

31592314_Pla

miR-451a

Down

< 0.0005

miR-21-5p

Down

< 0.005

miR-23a-3p

Down

< 0.005

let-7i-5p

Down

< 0.05

miR-126-3p

Down

< 0.005

miR-151a-3p

Down

< 0.05

31572518_Ser

miR-133b

Down

< 0.001

31420923_Pla

miR-103a-3p

Down

< 0.001

miR-107

Down

< 0.001

31092279_Pla

miR-92a-3p

Up

0.0442

miR-181c-5p

Up

0.0024

miR-210-3p

Up

0.0006

30914454_Pla

miR-101-3p

Down

< 0.001

miR-153-3p

Down

< 0.001

miR-144-3p

Down

< 0.001

miR-381-3p

Down

< 0.001

miR-383-5p

Down

< 0.001

30328325_Pla

miR-128-3p

Up

< 0.05

29966198_Pla

miR-146a-5p

Up

< 0.05

miR-933

Up

< 0.05

29746584_Ser

miR-103a-3p

Up

< 0.05

miR-142-3p

Up

< 0.05

miR-20a-5p

Up

< 0.05

miR-29b-3p

Up

< 0.05

let-7b-5p

Up

< 0.05

let-7 g-5p

Up

< 0.05

miR-106a-5p

Up

< 0.05

miR-106b-5p

Up

< 0.05

miR-18b-5p

Up

< 0.05

miR-223-3p

Up

< 0.05

miR-26a-5p

Up

< 0.05

miR-26b-5p

Up

< 0.05

miR-301a-3p

Up

< 0.05

miR-30b-5p

Up

< 0.05

miR-132-3p

Down

< 0.05

miR-146a-5p

Down

< 0.05

miR-15a-5p

Down

< 0.05

miR-22-3p

Down

< 0.05

miR-320a-3p

Down

< 0.05

miR-320b

Down

< 0.05

miR-92a-3p

Down

< 0.05

miR-1246

Down

< 0.05

29635818_Pla

miR-1908-5p

Up

< 0.05

29606187_Ser

miR-135a-5p

Up

< 0.05

miR-193b-3p

Down

< 0.01

miR-384

Up

< 0.05

29036829_WB

miR-144-5p

Down

0.03

miR-374a-5p

Down

0.034

miR-221-3p

Down

0.042

29036818_Ser_Mild

miR-106b-3p

Up

< 0.001

miR-26a-5p

Down

< 0.001

miR-181c-3p

Down

< 0.001

miR-126-5p

Down

< 0.001

miR-22-3p

Down

< 0.001

miR-148b-5p

Down

< 0.001

29036818_Ser_Mod

miR-106b-3p

Up

< 0.001

miR-1246

Up

< 0.001

miR-26a-5p

Down

< 0.001

miR-181c-3p

Down

< 0.001

miR-126-5p

Down

< 0.001

miR-22-3p

Down

< 0.001

miR-148b-5p

Down

< 0.001

29036818_Ser_Sev

miR-106b-3p

Up

< 0.001

miR-1246

Up

< 0.001

miR-660-5p

Up

< 0.001

miR-26a-5p

Down

0.007

miR-181c-3p

Down

< 0.001

miR-126-5p

Down

< 0.001

miR-22-3p

Down

< 0.001

miR-148b-5p

Down

< 0.001

28934394_Ser

miR-455-3p

Up

0.007

28849039_Ser_Mil

miR-222-3p

Down

< 0.05

28849039_Ser_Mod

miR-222-3p

Down

< 0.05

28626163_Ser

miR-146a-5p

Up

< 0.05

miR-106b-3p

Up

< 0.05

miR-195-5p

Up

< 0.05

miR-20b-5p

Up

< 0.05

miR-497-5p

Up

< 0.05

miR-29c-3p

Down

< 0.05

miR-93-5p

Down

< 0.05

miR-19b-3p

Down

< 0.05

miR-125b-3p

Down

< 0.05

28179587_Pla_AD2

miR-486-5p

Up

< 0.001

miR-483-5p

Up

< 0.0001

miR-502-3p

Up

< 0.0001

miR-200a-3p

Up

< 0.01

miR-151a-5p

Down

< 0.001

miR-30b-5p

Down

< 0.01

miR-103a-3p

Down

< 0.01

28179587_Pla_MCI-AD2

miR-486-5p

Up

< 0.001

miR-483-5p

Up

< 0.001

miR-502-3p

Up

< 0.01

miR-200a-3p

Up

< 0.05

28137310_Ser

miR-501-3p

Down

0.002

27545218_Ser

miR-613

Up

< 0.01

27501295_WB

miR-9-5p

Down

0.001

miR-106a-5p

Down

0.001

miR-106b-5p

Down

0.008

miR-107

Down

0.001

27446280_WB

miR-135b-5p

Down

< 0.01

27277332_WB

miR-206

Up

< 0.001

27239545_PBMC

miR-27b-3p

Up

< 0.05

miR-128-3p

Up

< 0.05

miR-155-5p

Up

< 0.05

27027823_Ser

miR-125b-5p

Down

< 0.001

miR-223-3p

Down

< 0.001

miR-29

Down

< 0.01

miR-519

Up

< 0.001

26973465_Pla

miR-10b-5p

Down

0.022

miR-29a-3p

Down

0.041

miR-130b-3p

Down

0.002

26497032_PBMC

miR-425-5p

Up

< 0.001

miR-339-5p

Up

0.003

miR-639

Down

0.04

26078483_Ser

miR-31-5p

Down

< 0.0001

miR-93-5p

Down

< 0.0001

miR-143-3p

Down

< 0.0001

miR-146a-5p

Down

< 0.0001

25955795_WB

miR-29c-3p

Down

0.0001

25742200_Pla

miR-107

Down

< 0.001

25667669_Ser

miR-210-3p

Down

< 0.01

25152461_Ser

miR-135a-5p

Down

< 0.05

miR-200b-3p

Down

< 0.05

24827165_Pla

miR-384

Down

< 0.05

24827165_Ser

miR-384

Down

< 0.05

24577456_Ser

miR-98-5p

Down

2.67 × 10E−4

miR-885-5p

Down

2.8 × 10E−4

miR-483-3p

Down

1.0 × 10E−4

miR-342-3p

Down

9.19 × 10E−16

miR-191-5p

Down

1.54 × 10E−9

let-7d-5p

Down

1.2 × 10E−6

24550773_Pla

miR-34c-5p

Up

< 0.01

24550773_PBMC

miR-34c-5p

Up

< 0.01

24157723_Pla

miR-34a-5p

Down

< 0.05

miR-146a-5p

Down

< 0.05

24139697_Ser

miR-125b-5p

Down

< 0.0001

miR-181c-5p

Down

< 0.0001

miR-9-5p

Up

0.0045

24064186_PBMC_Mon

miR-128-3p

Up

< 0.05

24064186_PBMC_Lym

miR-128-3p

Up

< 0.05

23922807_Pla_C2

let-7d-5p

Down

0.0001

let-7 g-5p

Down

0.001

miR-15b-5p

Down

0.001

miR-142-3p

Down

0.0001

miR-191-5p

Down

0.002

miR-545-3p

Down

0.03

23895045_WB

miR-151a-3p

Up

< 0.05

let-7d-3p

Up

< 0.05

miR-5010-3p

Up

< 0.05

let-7f-5p

Down

< 0.05

miR-1285-5p

Down

< 0.05

miR-107

Down

< 0.05

miR-103a-3p

Down

< 0.05

miR-26b-5p

Down

< 0.05

miR-26a-5p

Down

< 0.05

miR-532-5p

Down

< 0.05

23435408_PBMC

miR-29b-3p

Down

0.002

22155483_Ser

miR-137-3p

Down

< 0.05

miR-181c-5p

Down

< 0.05

miR-9-5p

Down

< 0.05

miR-29a-3p

Down

< 0.05

miR-29b-3p

Down

< 0.05

19936094_PBMC

miR-34a-5p

Up

< 0.05

miR-181b-5p

Up

< 0.05