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Table 1 Characteristics of the included differential miRNA expression studies

From: Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer’s disease by meta-analysis and adaptive boosting ensemble learning

PubMed ID Comparison ID Blood elements Differential miRNA expression profiling methods (screening method/validation method) Number of control case Number of AD case Number of upregulated miRNA Number of downregulated miRNA
31857133 31857133_Ser Serum qRT-PCR 93 108   1
31811079 31811079_Ser Serum qRT-PCR 51 32 9 3
31849573 31849573_Pla Plasma microRNA microarray/qRT-PCR 31 16   2
31809862 31809862_WB Whole blood qRT-PCR 214 145 1 1
31766231 31766231_Pla Plasma microRNA microarray/qRT-PCR 29 23 1  
31691877 31691877_Ser Serum qRT-PCR 30 30 4  
31592314 31592314_Pla Plasma RNA deep-sequencing/qRT-PCR 11 10   6
31572518 31572518_Ser Serum qRT-PCR 98 105   1
31420923 31420923_Pla Plasma qRT-PCR 120 120   2
31092279 31092279_Pla Plasma qRT-PCR 14 56 3  
30914454 30914454_Pla Plasma qRT-PCR 385 385   5
30328325 30328325_Pla Plasma qRT-PCR 20 20 1  
29966198 29966198_Pla Plasma qRT-PCR 10 10 2  
29746584 29746584_Ser Serum qRT-PCR 38 47 14 8
29635818 29635818_Pla Plasma qRT-PCR 20 20 1  
29606187 29606187_Ser Serum qRT-PCR 107 228 2 1
29036829 29036829_WB Whole blood microRNA microarray/qRT-PCR 17 21   3
29036818 29036818_Ser_Mild Serum RNA deep-sequencing/qRT-PCR 86 31 1 5
29036818_Ser_Mod Serum RNA deep-sequencing/qRT-PCR 86 52 3 5
29036818_Ser_Sev Serum RNA deep-sequencing/qRT-PCR 86 38 4 5
28934394 28934394_Ser Serum microRNA microarray/qRT-PCR 18 11 1  
28849039 28849039_Ser_Mil Serum microRNA microarray/qRT-PCR 30 30   1
28849039_Ser_Mod Serum microRNA microarray/qRT-PCR 30 30   1
28626163 28626163_Ser Serum RNA deep-sequencing/qRT-PCR 40 45 5 4
28179587 28179587_Pla_AD2 Plasma qRT-PCR 9 13 4 3
28179587_Pla_MCI-AD2 Plasma qRT-PCR 9 8 4  
28137310 28137310_Ser Serum RNA deep-sequencing/qRT-PCR 22 36   1
27545218 27545218_Ser Serum qRT-PCR 40 48 1  
27501295 27501295_WB Whole blood qRT-PCR 109 172   4
27446280 27446280_WB Whole blood qRT-PCR 25 25   1
27277332 27277332_WB Whole blood qRT-PCR 30 30 1  
27239545 27239545_PBMC Peripheral blood mononuclear cells qRT-PCR 36 36 3  
27027823 27027823_Ser Serum qRT-PCR 62 84 1 3
26973465 26973465_Pla Plasma microRNA microarray/qRT-PCR 40 40   3
26497032 26497032_PBMC Peripheral blood mononuclear cells microRNA microarray/qRT-PCR 41 45 2 1
26078483 26078483_Ser Serum RNA deep-sequencing/qRT-PCR 75 79   4
25955795 25955795_WB Whole blood qRT-PCR 30 30   1
25742200 25742200_Pla Plasma qRT-PCR 81 97   1
25667669 25667669_Ser Serum qRT-PCR 42 26   1
25152461 25152461_Ser Serum microRNA microarray/qRT-PCR 30 38   2
24827165 24827165_Pla Plasma qRT-PCR 7 7   1
  24827165_Ser Serum qRT-PCR 7 7   1
24577456 24577456_Ser Serum RNA deep-sequencing/qRT-PCR 155 158   6
24550773 24550773_Pla Plasma qRT-PCR 27 25 1  
24550773_PBMC Peripheral blood mononuclear cells qRT-PCR 27 25 1  
24157723 24157723_Pla Plasma qRT-PCR 10 10   2
24139697 24139697_Ser Serum qRT-PCR 155 105 1 2
24064186 24064186_PBMC_Mon Monocytes qRT-PCR 37 34 1  
24064186_PBMC_Lym Lymphocytes qRT-PCR 37 34 1  
23922807 23922807_Pla_C2 Plasma microRNA microarray/qRT-PCR 17 20   6
23895045 23895045_WB Whole blood RNA deep-sequencing/qRT-PCR 21 94 5 7
23435408 23435408_PBMC Peripheral blood mononuclear cells qRT-PCR 25 28   1
22155483 22155483_Ser Serum qRT-PCR 7 7   5
19936094 19936094_PBMC Peripheral blood mononuclear cells microRNA microarray/qRT-PCR 5 5 2