Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer’s disease by meta-analysis and adaptive boosting ensemble learning

Yuen, Sze Chung; Liang, Xiaonan; Zhu, Hongmei; Jia, Yongliang; Leung, Siu-wai

doi:10.1186/s13195-021-00862-z

Alzheimer's Research & Therapy

Table 1 Characteristics of the included differential miRNA expression studies

From: Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer’s disease by meta-analysis and adaptive boosting ensemble learning

PubMed ID	Comparison ID	Blood elements	Differential miRNA expression profiling methods (screening method/validation method)	Number of control case	Number of AD case	Number of upregulated miRNA	Number of downregulated miRNA
31857133	31857133_Ser	Serum	qRT-PCR	93	108		1
31811079	31811079_Ser	Serum	qRT-PCR	51	32	9	3
31849573	31849573_Pla	Plasma	microRNA microarray/qRT-PCR	31	16		2
31809862	31809862_WB	Whole blood	qRT-PCR	214	145	1	1
31766231	31766231_Pla	Plasma	microRNA microarray/qRT-PCR	29	23	1
31691877	31691877_Ser	Serum	qRT-PCR	30	30	4
31592314	31592314_Pla	Plasma	RNA deep-sequencing/qRT-PCR	11	10		6
31572518	31572518_Ser	Serum	qRT-PCR	98	105		1
31420923	31420923_Pla	Plasma	qRT-PCR	120	120		2
31092279	31092279_Pla	Plasma	qRT-PCR	14	56	3
30914454	30914454_Pla	Plasma	qRT-PCR	385	385		5
30328325	30328325_Pla	Plasma	qRT-PCR	20	20	1
29966198	29966198_Pla	Plasma	qRT-PCR	10	10	2
29746584	29746584_Ser	Serum	qRT-PCR	38	47	14	8
29635818	29635818_Pla	Plasma	qRT-PCR	20	20	1
29606187	29606187_Ser	Serum	qRT-PCR	107	228	2	1
29036829	29036829_WB	Whole blood	microRNA microarray/qRT-PCR	17	21		3
29036818	29036818_Ser_Mild	Serum	RNA deep-sequencing/qRT-PCR	86	31	1	5
	29036818_Ser_Mod	Serum	RNA deep-sequencing/qRT-PCR	86	52	3	5
	29036818_Ser_Sev	Serum	RNA deep-sequencing/qRT-PCR	86	38	4	5
28934394	28934394_Ser	Serum	microRNA microarray/qRT-PCR	18	11	1
28849039	28849039_Ser_Mil	Serum	microRNA microarray/qRT-PCR	30	30		1
28849039	28849039_Ser_Mod	Serum	microRNA microarray/qRT-PCR	30	30		1
28626163	28626163_Ser	Serum	RNA deep-sequencing/qRT-PCR	40	45	5	4
28179587	28179587_Pla_AD2	Plasma	qRT-PCR	9	13	4	3
28179587	28179587_Pla_MCI-AD2	Plasma	qRT-PCR	9	8	4
28137310	28137310_Ser	Serum	RNA deep-sequencing/qRT-PCR	22	36		1
27545218	27545218_Ser	Serum	qRT-PCR	40	48	1
27501295	27501295_WB	Whole blood	qRT-PCR	109	172		4
27446280	27446280_WB	Whole blood	qRT-PCR	25	25		1
27277332	27277332_WB	Whole blood	qRT-PCR	30	30	1
27239545	27239545_PBMC	Peripheral blood mononuclear cells	qRT-PCR	36	36	3
27027823	27027823_Ser	Serum	qRT-PCR	62	84	1	3
26973465	26973465_Pla	Plasma	microRNA microarray/qRT-PCR	40	40		3
26497032	26497032_PBMC	Peripheral blood mononuclear cells	microRNA microarray/qRT-PCR	41	45	2	1
26078483	26078483_Ser	Serum	RNA deep-sequencing/qRT-PCR	75	79		4
25955795	25955795_WB	Whole blood	qRT-PCR	30	30		1
25742200	25742200_Pla	Plasma	qRT-PCR	81	97		1
25667669	25667669_Ser	Serum	qRT-PCR	42	26		1
25152461	25152461_Ser	Serum	microRNA microarray/qRT-PCR	30	38		2
24827165	24827165_Pla	Plasma	qRT-PCR	7	7		1
	24827165_Ser	Serum	qRT-PCR	7	7		1
24577456	24577456_Ser	Serum	RNA deep-sequencing/qRT-PCR	155	158		6
24550773	24550773_Pla	Plasma	qRT-PCR	27	25	1
24550773	24550773_PBMC	Peripheral blood mononuclear cells	qRT-PCR	27	25	1
24157723	24157723_Pla	Plasma	qRT-PCR	10	10		2
24139697	24139697_Ser	Serum	qRT-PCR	155	105	1	2
24064186	24064186_PBMC_Mon	Monocytes	qRT-PCR	37	34	1
24064186	24064186_PBMC_Lym	Lymphocytes	qRT-PCR	37	34	1
23922807	23922807_Pla_C2	Plasma	microRNA microarray/qRT-PCR	17	20		6
23895045	23895045_WB	Whole blood	RNA deep-sequencing/qRT-PCR	21	94	5	7
23435408	23435408_PBMC	Peripheral blood mononuclear cells	qRT-PCR	25	28		1
22155483	22155483_Ser	Serum	qRT-PCR	7	7		5
19936094	19936094_PBMC	Peripheral blood mononuclear cells	microRNA microarray/qRT-PCR	5	5	2

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ISSN: 1758-9193

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