Fig. 2
CSF levels of VAMP-2 in non-trisomic controls and DS. a Violin plots show the distribution of SRM intensities for VAMP-2 quantified in CSF for non-trisomic cognitively normal subjects (controls) and adults with DS across AD stages; asymptomatic AD (aDS), prodromal AD (pDS) or AD dementia (dDS). The horizontal dotted line represents the mean value in controls. *p < .05, **p < .01 for linear regression using square root transformed VAMP-2 levels in 1 DS vs controls, 2 aDS vs controls and 3 pDS/dDS vs aDS. b Age-at-analysis (years) is plotted against VAMP-2 SRM intensities in controls and adults with DS. c CSF biomarkers; Aβ42:40 ratio, p-tau and NFL are plotted against VAMP-2 SRM intensities in adults with DS. Linear regression lines in b and c are shown for each group (see legends). Shaded areas represent standard error of the regression lines. The vertical dotted lines in c represent the validated cut-offs for biomarker positivity in sporadic AD