Fig. 3
From: Race, APOE genotypes, and cognitive decline among middle-aged urban adults
APOE4 allelic dosage vs. BTA trajectories among African American women and men: predictive margins from mixed-effects linear regression modela. Abbreviations: APOE = Apolipoprotein E; BTA = Brief Test of Attention; HANDLS = Healthy Aging in Neighborhoods of Diversity across the Life Span. a Model 2E, Table 2, fully adjusted model, stratified by race and sex. Figure shows predictive margins of BTA scores across time with their 95% CI, highlighting the significant difference in slope across APOE4 dosage among African American women only. γ12 refers to the fixed effect of APOE4 dosage on the rate of change in BTA total score for each sex group among African Americans. “b” is a standardized measure for the regression coefficient γ12 in model where BTA is entered as standardized z-scores within each racial/sex group. It is interpreted as the SD of outcome change per year increase in follow-up time for each APOE4 dosage change. 1 SD of BTA corresponds to 6.63 change in score, overall