Fig. 1
a Q-Q plot. b Manhattan plot of GWAS analysis. c Regional association plot of rs73375428. The dotted line in the Manhattan plot indicate the genome-wide significance level (p = 5.0 × 10−8, gray dotted line) and the genome-wide suggestive level (p = 1.0 × 10−6, red dotted line; p = 1.0 × 10−5, blue dotted line), respectively. Regional association plot was modified from the SNiPA (single nucleotide polymorphism annotator) (https://snipa.helmholtz-muenchen.de/snipa3). GWAS, genome-wide association study; MAF, minor allele frequency; Q-Q plot, quantile-quantile plot; SNP, single nucleotide polymorphism; SPDYE18, speedy/RINGO cell cycle regulator family member E18; PMS2P9, PMS1 homolog2 mismatch repair system component pseudogene 9; FAM185BP, family with sequence similarity 185 member A pseudogene; SPDYE17, speedy/RINGO cell cycle regulator family member E17; 1-UPK3BP1-PMS2P11, uroplakin 3B pseudogene 1- PMS1 homolog2 mismatch repair system component pseudogene11; FGL2, fibrinogen-like protein 2; CCDC146, coiled-coil domain containing 146; GSAP, gamma secretase activating protein; GCNT1P5, glucosaminyl transferase 1 pseudogene 5