Fig. 2
PWV predicts executive function beyond age and sex and interacts with APOE genotype and AD CSF biomarkers to predict memory performance. A Cognitive domain z-scores are shown as a function of PWV. Regression models adjusted for age, sex, education, and FSRP (excluding age points) demonstrate a significant main effect of PWV on executive function (p = 0.03). B The same cases were classified based on APOE genotype as APOE ε4+ (ε2ε4, ε3ε4, ε4ε4) or APOE ε4 − (ε2ε2, ε2ε3, ε3ε3). In regression models examining the interaction of PWV and APOE genotype, a significant interaction (p = 0.01) suggested that PWV was more predictive of memory scores in those that were APOE ε4+. C In a subset of patients with CSF biomarkers, individuals were classified into AD-like and non-AD profiles based on the tau/Aβ1–42 ratio. In regression models examining the interaction of PWV and CSF AD biomarker status, a significant interaction (p = 0.02) suggests that PWV was similarly more predictive of memory z-scores in those that were AD-like in their profile