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Table 1 Demographic, clinical, and neuropsychological characteristics of study participants

From: Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer’s disease

Variable Mutation carriers (n = 18) Non-carriers (n = 21) p value
Demographic data
 Female, n (%) 8 (44.4) 11 (52.4) 0.751
 Age, y 38.0 (35.8–43.0) 35.0 (33.0–48.0) 0.282
 Estimated proximity to onset, y 11.0 (7.8–15.5) NA  
 Education, y 14.0 (11.0–15.3) 16.0 (11.5–16.5) 0.094
Cognitive level (global)
 MMSE score 29.5 (29.0–30.0) 30.0 (29.0–30.0) 0.512
 MoCA score 28.0 (27.0–28.0) 27.0 (27.0–28.5) 0.606
SCD-Q MyCog
 Total score 6.0 (2.0–9.3) 2.0 (0.5–7.0) 0.272
 Memory subscore 4.0 (1.8–6.0) 2.0 (0–4.5) 0.185
 Language subscore 1.0 (0–2.0) 0 (0–1.0) 0.262
 Executive subscore 1.0 (0–1.5) 0 (0–1.0) 0.150
Senescence-related factor
 CCL11, pg/ml 77.4 (64.1–92.4) 76.9 (51.2–90.6) 0.455
 MCP1, pg/ml 179.0 (137.3–212.3) 149.4 (122.5–194.2) 0.537
 GDF11, pg/ml 87.9 (52.6–118.2) 72.6 (42.4–91.2) 0.673
 THBS4, ng/ml 120.7 (85.2–161.3) 159.4 (117.5–217.5) 0.530
 SPARCL1, ng/ml 5.4 (3.9–7.3) 5.2 (4.1–6.8) 0.749
  1. For continuous variables, data are shown as median (IQR), and the Mann–Whitney U test was used for group comparison; for categorical variables, the chi-square test was used for group comparison
  2. Abbreviations: CCL11 CC chemokine ligand 11, GDF11 growth differentiation factor 11, MCP1 monocyte chemotactic protein 1, MMSE Mini-Mental State Examination, MoCA Montreal Cognitive Assessment, NA not applicable, SCD-Q Subjective Cognitive Decline Questionnaire, SPARCL1 secreted protein acidic and rich in cysteine like 1, THBS4 thrombospondin-4