Variable | Mutation carriers (n = 18) | Non-carriers (n = 21) | p value |
---|---|---|---|
Demographic data | |||
Female, n (%) | 8 (44.4) | 11 (52.4) | 0.751 |
Age, y | 38.0 (35.8–43.0) | 35.0 (33.0–48.0) | 0.282 |
Estimated proximity to onset, y | 11.0 (7.8–15.5) | NA | |
Education, y | 14.0 (11.0–15.3) | 16.0 (11.5–16.5) | 0.094 |
Cognitive level (global) | |||
MMSE score | 29.5 (29.0–30.0) | 30.0 (29.0–30.0) | 0.512 |
MoCA score | 28.0 (27.0–28.0) | 27.0 (27.0–28.5) | 0.606 |
SCD-Q MyCog | |||
Total score | 6.0 (2.0–9.3) | 2.0 (0.5–7.0) | 0.272 |
Memory subscore | 4.0 (1.8–6.0) | 2.0 (0–4.5) | 0.185 |
Language subscore | 1.0 (0–2.0) | 0 (0–1.0) | 0.262 |
Executive subscore | 1.0 (0–1.5) | 0 (0–1.0) | 0.150 |
Senescence-related factor | |||
CCL11, pg/ml | 77.4 (64.1–92.4) | 76.9 (51.2–90.6) | 0.455 |
MCP1, pg/ml | 179.0 (137.3–212.3) | 149.4 (122.5–194.2) | 0.537 |
GDF11, pg/ml | 87.9 (52.6–118.2) | 72.6 (42.4–91.2) | 0.673 |
THBS4, ng/ml | 120.7 (85.2–161.3) | 159.4 (117.5–217.5) | 0.530 |
SPARCL1, ng/ml | 5.4 (3.9–7.3) | 5.2 (4.1–6.8) | 0.749 |