|
Variable
|
Mutation carriers (n = 18)
|
Non-carriers (n = 21)
|
p value
|
|---|
|
Demographic data
|
|
Female, n (%)
|
8 (44.4)
|
11 (52.4)
|
0.751
|
|
Age, y
|
38.0 (35.8–43.0)
|
35.0 (33.0–48.0)
|
0.282
|
|
Estimated proximity to onset, y
|
11.0 (7.8–15.5)
|
NA
| |
|
Education, y
|
14.0 (11.0–15.3)
|
16.0 (11.5–16.5)
|
0.094
|
|
Cognitive level (global)
|
|
MMSE score
|
29.5 (29.0–30.0)
|
30.0 (29.0–30.0)
|
0.512
|
|
MoCA score
|
28.0 (27.0–28.0)
|
27.0 (27.0–28.5)
|
0.606
|
|
SCD-Q MyCog
|
|
Total score
|
6.0 (2.0–9.3)
|
2.0 (0.5–7.0)
|
0.272
|
|
Memory subscore
|
4.0 (1.8–6.0)
|
2.0 (0–4.5)
|
0.185
|
|
Language subscore
|
1.0 (0–2.0)
|
0 (0–1.0)
|
0.262
|
|
Executive subscore
|
1.0 (0–1.5)
|
0 (0–1.0)
|
0.150
|
|
Senescence-related factor
|
|
CCL11, pg/ml
|
77.4 (64.1–92.4)
|
76.9 (51.2–90.6)
|
0.455
|
|
MCP1, pg/ml
|
179.0 (137.3–212.3)
|
149.4 (122.5–194.2)
|
0.537
|
|
GDF11, pg/ml
|
87.9 (52.6–118.2)
|
72.6 (42.4–91.2)
|
0.673
|
|
THBS4, ng/ml
|
120.7 (85.2–161.3)
|
159.4 (117.5–217.5)
|
0.530
|
|
SPARCL1, ng/ml
|
5.4 (3.9–7.3)
|
5.2 (4.1–6.8)
|
0.749
|
- For continuous variables, data are shown as median (IQR), and the Mann–Whitney U test was used for group comparison; for categorical variables, the chi-square test was used for group comparison
- Abbreviations: CCL11 CC chemokine ligand 11, GDF11 growth differentiation factor 11, MCP1 monocyte chemotactic protein 1, MMSE Mini-Mental State Examination, MoCA Montreal Cognitive Assessment, NA not applicable, SCD-Q Subjective Cognitive Decline Questionnaire, SPARCL1 secreted protein acidic and rich in cysteine like 1, THBS4 thrombospondin-4
