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Table 1 Demographics of the ADNI and UPenn datasets

From: Pathological drivers of neurodegeneration in suspected non-Alzheimer’s disease pathophysiology

  ADNI UPenn
A−N− SNAP A+N+ A−N− SNAP A+N+
Number (%) 6 (9.5) 14 (22.2) 35 (55.6) 11 (7.1) 47 (30.1) 76 (48.7)
Age at death (years) 84.5±3.8 83.6±8.4 82.0±6.9 68.6±5.9 68.9±9.8 74.2±11.8*
Gender (% male) 4 (66.7) 14 (100) 27 (77.1) 8 (72.7) 47 (61.8) 26 (55.3)
Time difference between MRI and date of death (years) 4.5±2.1 5.9±2.8 4.3±2.5 2.1±2.5 2.1±2.0 3.2±2.5*
Clinical diagnosis at MRI
 Control (%) 4 (66.7) 1 (7.1) 2 (5.7) 0 (0) 0 (0) 0 (0)
 MCI (%) 2 (33.3) 11 (78.6) 16 (45.7) 0 (0) 1 (2.1) 6 (7.9)
 Dementia (%) 0 (0) 2 (14.3) 17 (48.6) 11 (100) 46 (97.9) 69 (90.8)
 Others (%) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 1 (1.3)a
Latest clinical diagnosis
 Control (%) 3 (50.0) 1 (7.1) 0 (0) 0 (0) 0 (0) 0 (0)
 MCI (%) 2 (33.3) 2 (14.3) 4 (11.4) 0 (0) 1 (2.1) 4 (5.3)
 Dementia (%) 1 (16.7) 3 (78.6) 31 (88.6) 11 (100) 46 (97.9) 72 (94.7)
  1. <0.10; *p<0.05 for comparison with SNAP. aThis case had a clinical diagnosis of Parkinson’s disease but a neuropathological diagnosis of progressive supranuclear palsy. SNAP suspected non-Alzheimer’s pathophysiology, A β-amyloid, N neurodegeneration, MCI mild cognitive impairment