From: Investigating the relationship between BMI across adulthood and late life brain pathologies
WBV β coefficient (95% CI) | Mean HV β coefficient (95% CI) | ||||||
---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | ||
Age 36 Model 1: n = 407 Model 2: n = 403 Model 3: n = 401 | BMI | 1.1 (− 0.4, 2.5) | 1.0 (− 0.4, 2.5) | 1.3 (− 0.2, 2.7) | 0.011 (0.002, 0.020) | 0.010 (0.001, 0.020) | 0.009 (0, 0.019) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | 1.15 (− 9.5, 11.8) | 1.2 (− 9.5, 11.9) | 2.2 (−8.4, 12.9) | 0.031 (− 0.036, 0.099) | 0.028 (− 0.039, 0.095) | 0.029 (− 0.040, 0.097) | |
Obese | 18.8 (−6.1, 43.6) | 19.1 (−5.9, 44.0) | 21.9 (−3.0, 46.8) | 0.192 (0.034, 0.349) | 0.188 (0.031, 0.345) | 0.167 (0.007, 0.327) | |
Age 43 Model 1: n = 426 Model 2: n = 420 Model 3: n = 416 | BMI | 1.0 (− 0.4, 2.3) | 1.1 (− 0.3, 2.4) | 1.1 (− 0.2, 2.5) | 0.006 (− 0.002, 0.015) | 0.006 (− 0.003, 0.015) | 0.004 (− 0.005, 0.013) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | 6.0 (− 3.2, 15.2) | 6.5 (− 2.8, 15.7) | 7.6 (−1.6, 16.9) | 0.041 (− 0.017, 0.100) | 0.044 (− 0.015, 0.103) | 0.035 (− 0.025, 0.094) | |
Obese | 16.5 (− 0.5, 33.6) | 17.1 (− 0.2, 34.4) | 16.8 (− 0.6, 34.2) | 0.072 (− 0.037, 0.180) | 0.057 (− 0.053, 0.167) | 0.047 (− 0.065, 0.159) | |
Age 53 Model 1: n = 436 Model 2: n = 432 Model 3: n = 428 | BMI | 0.3 (− 0.7, 1.3) | 0.6 (− 0.4, 1.7) | 0.8 (− 0.2, 1.9) | 0.005 (− 0.002, 0.011) | 0.006 (− 0.001, 0.013) | 0.005 (− 0.003, 0.012) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | − 2.3 (− 11.8, 7.3) | − 0.6 (− 10.2, 9.0) | 0.3 (− 9.4, 9.9) | 0.008 (− 0.054, 0.069) | 0.013 (− 0.049, 0.075) | − 0.001 (− 0.065, 0.062) | |
Obese | 6.3 (−6.1, 18.7) | 9.6 (−3.2, 22.5) | 11.1 (− 1.8, 24.0) | 0.062 (− 0.017, 0.142) | 0.079 (− 0.004, 0.162) | 0.063 (− 0.021, 0.148) | |
Age 60–64 Model 1: n = 445 Model 2: n = 444 Model 3: n = 440 | BMI | − 0.2 (− 1.2, 0.8) | − 0.1 (− 1.1, 0.9) | 0.2 (− 0.9, 1.2) | 0.005 (− 0.001, 0.012) | 0.006 (0, 0.013) | 0.005 (− 0.002, 0.011) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | − 0.5 (− 10.4, 9.4) | 0.2 (− 9.7, 10.2) | 0.5 (− 9.5, 10.4) | 0.077 (0.014, 0.140) | 0.083 (0.019, 0.147) | 0.073 (0.009, 0.137) | |
Obese | −2.6 (−13.7, 8.4) | −1.3 (− 12.5, 10.0) | − 0.2 (− 11.7, 11.4) | 0.066 (− 0.005, 0.136) | 0.076 (0.005, 0.148) | 0.059 (− 0.015, 0.134) | |
Age 69 Models 1, 2 and 3: n = 438 | BMI | − 0.3 (− 1.2, 0.7) | − 0.2 (− 1.2, 0.7) | 0.0 (−1.0, 1.0) | 0.005 (− 0.002, 0.011) | 0.005 (− 0.001, 0.011) | 0.004 (− 0.002, 0.010) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | 1.6 (− 8.3, 11.6) | 1.7 (− 8.3, 11.6) | 3.4 (− 6.5, 13.4) | 0.077 (0.013, 0.140) | 0.077 (0.013, 0.140) | 0.076 (0.012, 0.140) | |
Obese | − 3.4 (−14.5, 7.7) | −2.5 (− 13.8, 8.7) | 0.1 (− 11.2, 11.3) | 0.046 (− 0.025, 0.116) | 0.049 (− 0.022, 0.121) | 0.040 (− 0.033, 0.112) | |
Age 71 Model 1: n = 445 Model 2: n = 444 Model 3: n = 440 | BMI | − 0.2 (− 1.2, 0.7) | − 0.1 (− 1.1, 0.8) | 0.0 (− 0.9, 1.0) | 0.005 (− 0.001, 0.011) | 0.006 (0, 0.012) | 0.004 (− 0.002, 0.010) |
Normal weight | REF | REF | REF | REF | REF | REF | |
Overweight | 3.6 (−6.2, 13.5) | 4.9 (−5.0, 14.8) | 4.5 (−5.4, 14.4) | 0.097 (0.034, 0.159) | 0.108 (0.045, 0.171) | 0.101 (0.037, 0.165) | |
Obese | − 4.3 (−15.3, 6.7) | − 3.0 (− 14.1, 8.0) | − 1.6 (− 12.8, 9.7) | 0.078 (0.009, 0.148) | 0.090 (0.020, 0.161) | 0.076 (0.003, 0.149) |