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Table 3 Associations between BMI and weight across adulthood, and WBV and mean HV at age 71

From: Investigating the relationship between BMI across adulthood and late life brain pathologies

 

WBV β coefficient (95% CI)

Mean HV β coefficient (95% CI)

Model 1

Model 2

Model 3

Model 1

Model 2

Model 3

Age 36

Model 1: n = 407

Model 2: n = 403

Model 3: n = 401

BMI

1.1 (− 0.4, 2.5)

1.0 (− 0.4, 2.5)

1.3 (− 0.2, 2.7)

0.011 (0.002, 0.020)

0.010 (0.001, 0.020)

0.009 (0, 0.019)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

1.15 (− 9.5, 11.8)

1.2 (− 9.5, 11.9)

2.2 (−8.4, 12.9)

0.031 (− 0.036, 0.099)

0.028 (− 0.039, 0.095)

0.029 (− 0.040, 0.097)

Obese

18.8 (−6.1, 43.6)

19.1 (−5.9, 44.0)

21.9 (−3.0, 46.8)

0.192 (0.034, 0.349)

0.188 (0.031, 0.345)

0.167 (0.007, 0.327)

Age 43

Model 1: n = 426

Model 2: n = 420

Model 3: n = 416

BMI

1.0 (− 0.4, 2.3)

1.1 (− 0.3, 2.4)

1.1 (− 0.2, 2.5)

0.006 (− 0.002, 0.015)

0.006 (− 0.003, 0.015)

0.004 (− 0.005, 0.013)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

6.0 (− 3.2, 15.2)

6.5 (− 2.8, 15.7)

7.6 (−1.6, 16.9)

0.041 (− 0.017, 0.100)

0.044 (− 0.015, 0.103)

0.035 (− 0.025, 0.094)

Obese

16.5 (− 0.5, 33.6)

17.1 (− 0.2, 34.4)

16.8 (− 0.6, 34.2)

0.072 (− 0.037, 0.180)

0.057 (− 0.053, 0.167)

0.047 (− 0.065, 0.159)

Age 53

Model 1: n = 436

Model 2: n = 432

Model 3: n = 428

BMI

0.3 (− 0.7, 1.3)

0.6 (− 0.4, 1.7)

0.8 (− 0.2, 1.9)

0.005 (− 0.002, 0.011)

0.006 (− 0.001, 0.013)

0.005 (− 0.003, 0.012)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

− 2.3 (− 11.8, 7.3)

− 0.6 (− 10.2, 9.0)

0.3 (− 9.4, 9.9)

0.008 (− 0.054, 0.069)

0.013 (− 0.049, 0.075)

− 0.001 (− 0.065, 0.062)

Obese

6.3 (−6.1, 18.7)

9.6 (−3.2, 22.5)

11.1 (− 1.8, 24.0)

0.062 (− 0.017, 0.142)

0.079 (− 0.004, 0.162)

0.063 (− 0.021, 0.148)

Age 60–64

Model 1: n = 445

Model 2: n = 444

Model 3: n = 440

BMI

− 0.2 (− 1.2, 0.8)

− 0.1 (− 1.1, 0.9)

0.2 (− 0.9, 1.2)

0.005 (− 0.001, 0.012)

0.006 (0, 0.013)

0.005 (− 0.002, 0.011)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

− 0.5 (− 10.4, 9.4)

0.2 (− 9.7, 10.2)

0.5 (− 9.5, 10.4)

0.077 (0.014, 0.140)

0.083 (0.019, 0.147)

0.073 (0.009, 0.137)

Obese

−2.6 (−13.7, 8.4)

−1.3 (− 12.5, 10.0)

− 0.2 (− 11.7, 11.4)

0.066 (− 0.005, 0.136)

0.076 (0.005, 0.148)

0.059 (− 0.015, 0.134)

Age 69

Models 1, 2 and 3: n = 438

BMI

− 0.3 (− 1.2, 0.7)

− 0.2 (− 1.2, 0.7)

0.0 (−1.0, 1.0)

0.005 (− 0.002, 0.011)

0.005 (− 0.001, 0.011)

0.004 (− 0.002, 0.010)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

1.6 (− 8.3, 11.6)

1.7 (− 8.3, 11.6)

3.4 (− 6.5, 13.4)

0.077 (0.013, 0.140)

0.077 (0.013, 0.140)

0.076 (0.012, 0.140)

Obese

− 3.4 (−14.5, 7.7)

−2.5 (− 13.8, 8.7)

0.1 (− 11.2, 11.3)

0.046 (− 0.025, 0.116)

0.049 (− 0.022, 0.121)

0.040 (− 0.033, 0.112)

Age 71

Model 1: n = 445

Model 2: n = 444

Model 3: n = 440

BMI

− 0.2 (− 1.2, 0.7)

− 0.1 (− 1.1, 0.8)

0.0 (− 0.9, 1.0)

0.005 (− 0.001, 0.011)

0.006 (0, 0.012)

0.004 (− 0.002, 0.010)

Normal weight

REF

REF

REF

REF

REF

REF

Overweight

3.6 (−6.2, 13.5)

4.9 (−5.0, 14.8)

4.5 (−5.4, 14.4)

0.097 (0.034, 0.159)

0.108 (0.045, 0.171)

0.101 (0.037, 0.165)

Obese

− 4.3 (−15.3, 6.7)

− 3.0 (− 14.1, 8.0)

− 1.6 (− 12.8, 9.7)

0.078 (0.009, 0.148)

0.090 (0.020, 0.161)

0.076 (0.003, 0.149)

  1. β-coefficients represent the change in brain volume (ml) per 1 unit change in BMI or change in weight status using normal weight as the reference group. 95% confidence intervals are also shown. Associations significant at p < 0.05 are highlighted in bold. Model numbers are stated in the left-hand column. Model 1 adjusted for TIV, sex and age at scanning; Model 2 also adjusted for contemporaneous SBP; Model 3 also adjusted for adult SEP, DM, hypercholesterolaemia, smoking status, β-amyloid status and global WMHV. BMI body mass index, CI confidence interval, DM diabetes mellitus, HV hippocampal volume, REF reference, SBP systolic blood pressure, SEP socioeconomic position, TIV total intracranial volume, WBV whole brain volume, WMHV white matter hyperintensity volume