Fig. 2

While DC and AD groups in study cohort 1 did not show a significant age difference (a), AD patients showed significantly elevated b total Tau and c pTau181 levels. An analysis of CSF Aβ peptides revealed unchanged d Aβ₃₈ and e Aβ₄₀ levels, but significantly reduced f Aβ₄₂ and g Aβ_42/40 ratios in the AD group. h CSF GPNMB levels were not significantly altered and a ROC analysis i with GPNMB CSF levels showed only poor discrimination between the groups (AUC = 0.59); ****p < 0.0001