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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Prognostic value of amyloid/tau/neurodegeneration (ATN) classification based on diagnostic cerebrospinal fluid samples for Alzheimer’s disease

Fig. 3

Interaction of individual continuous CSF biomarkers on the slope of MMSE within ATN classes. The more negative the value of the slope, the steeper the cognitive decline. a The effect of CSF ratio Aβ42/t-tau. b The effect of Aβ42. c The effect of CSF t-tau. d The effect of p181-tau. The dashed line corresponds to the CSF cut-off for each particular biomarker. MMSE, Mini Mental State Examination; CSF, cerebrospinal fluid; Aβ42, amyloid-beta 1–42; t-tau, total tau; p181-tau, hyperphosphorylated tau at threonine 181

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