Table 5 Effects of HTL0018318 on the performance of the Milner maze test reversed condition
| Â | Younger adults | Elderly | ||||
|---|---|---|---|---|---|---|
Parameter | Day 1 | Day 5 | Day 10 | Day 1 | Day 5 | Day 10 |
15 mg HTL0018318 | ||||||
 MMTRev: Expl Error | −1.9 (− 3.7, − 0.1) p = 0.0359 ES = 1.00 | − 0.5 (− 2.2, 1.3) p = 0.6108 ES = 0.24 | − 1.0 (− 2.8, 0.8) p = 0.2737 ES = 0.52 | − 1.4 (− 3.2, 0.3) p = 0.1011 ES = 0.76 | − 1.9 (− 3.6, − 0.2) p = 0.0322 ES = 1.00 | − 0.7 (− 2.5, 1.0) p = 0.4115 ES = 0.38 |
20 mg HTL0018318 | ||||||
 MMTRev: Expl Error | −1.1 (− 2.9, 0.7) p = 0.2347 ES = 0.57 | − 0.0 (− 1.8, 1.7) p = 0.9592 ES = 0.02 | 0.3 (− 1.5, 2.1) p = 0.7500 ES = 0.15 | − 1.8 (− 3.5, − 0.0) p = 0.0487 ES = 0.92 | − 2.0 (− 3.7, − 0.2) p = 0.0284 ES = 1.03 | − 1.3 (− 3.0, 0.5) p = 0.1593 ES = 0.66 |
25 mg HTL0018318 | ||||||
 MMTRev: Expl Error | −2.2 (− 3.9, − 0.4) p = 0.0174 ES = 1.14 | − 0.1 (− 1.9, 1.7) p = 0.9334 ES = 0.04 | − 1.4 (− 3.2, 0.4) p = 0.1219 ES = 0.75 | − 2.0 (− 3.8, − 0.3) p = 0.0217 ES = 1.08 | − 1.7 (− 3.5, 0.1) p = 0.0577 ES = 0.90 | − 1.9 (− 3.7, − 0.1) p = 0.0431 ES = 0.99 |
(20 + 35 mg) HTL0018318 | ||||||
 MMTRev: Expl Error |  |  |  | −2.9 (−5.7, − 0.1) p = 0.0457 ES = 1.05 | − 3.3 (− 6.1, − 0.5) p = 0.0230 ES = 1.20 | − 2.6 (− 5.4, 0.2) p = 0.0718 ES = 0.93 |