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Table 5 Analytes associated with CSF P-Tau

From: An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer’s disease

 

Coeff.

Lipidomics

 PC 34:1

75.7244

 PC 32:0

41.1825

 DAG 34:0

32.4248

 SE 27:1 18:1

9.313

 LPE 22:6

1.2951

 SE 27:1 18:2

− 13.6849

Metabolomics

 Glycoproteins

42.4426

 3-Hydroxyisovaleric acid

15.143

 S61

− 0.3484

 S59

− 1.5514

 S56

− 15.8893

One-carbon metabolism

 S-adenosylhomocysteine

48.6705

 5-Methyltetrahydrofolate

− 72.7586

Proteomics

 SPARC-related modular calcium binding 1

4.388161

 Brain abundant membrane attached signal protein 1

4.028155

 Neuromodulin

1.626098

 Thymosin beta-10

1.291504

 14-3-3 protein zeta/delta

1.10139

 Pyruvate kinase PKM

0.189499

  1. Analytes within the whole cohort with a significant association with CSF P-Tau sorted by decreasing absolute association strength within each modality. For each analyte, the coefficient obtained by Elastic-Net regression is shown. S56, S59 and S61 represent different unidentified metabolites