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Table 3 Analytes associated with CSF Aβ1-42

From: An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer’s disease

 

Coeff.

Neuroinflammation

 C-reactive protein

17.9542

 Monocyte chemoattractant protein-1

− 78.6254

Proteomics

 Spermine synthase

109.3853

 WAP four-disulfide core domain protein 2

93.78915

 Ephrin-B2

72.52614

 Neuroendocrine convertase 2

55.25737

 WAP four-disulfide core domain protein 1

42.96994

 Spectrin beta chain, non-erythrocytic 5

37.99513

 Neuropentraxin2

37.29243

 Chondroadherin

32.78591

 Reelin

19.927

 Sodium/potassium-transporting ATPase subunit alpha-2

17.62631

 von Willebrand factor

17.59776

 Mast/stem cell growth factor receptor kit

17.49956

 Lymphatic vessel endothelial hyaluronic acid receptor 1

7.896977

 Neurotrimin

1.179857

 Acid ceramidase

0.892224

 Protein shisa-6

0.412964

 Monocyte chemoattractant protein 1

−12.5945

 SPARC related modular calcium binding 1

− 186.61

 14-3-3 protein zeta/delta

− 230.535

  1. Analytes within the whole cohort with a significant association with CSF Aβ1-42 sorted by decreasing absolute association strength within each modality. For each analyte, the coefficient obtained by Elastic-Net regression is shown
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Alzheimer's Research & Therapy

ISSN: 1758-9193