An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer’s disease

Table 1 Datasets used in this study

Dataset	Analytes initial/final	Quantification technique	References
Proteomics	791/768	LC-MS/MS	[23, 24]
Neuroinflammation	38/21	Multi-array sandwich immunoassay	[29,30,31]
One-carbon metabolism	17/9	LC-MS/MS	[28, 32]
Metabolomics	71/63	¹H NMR	[27]
Lipidomics	65/26	MS	[26, 33]
Biomarkers of core AD pathology	3/3	ELISA	[30]

Available datasets from the cohort along with the number of analytes measured in this study and the associated quantification methods. For each dataset the initial number of analytes quantified, the number of measurements remaining after quality control, quantification technique used, and technical references are indicated. LC-MS/MS, liquid chromatography tandem mass spectrometry; ¹H NMR, proton nuclear magnetic resonance; MS, mass spectrometry; ELISA, enzyme-linked immunosorbent assay

ISSN: 1758-9193