Fig. 3

Aducanumab analog does not affect levels of cerebral amyloid angiopathy (CAA) or microhemorrhages in APP23 mice. a Representative Campbell-Switzer silver staining shows CAA in the cortex identified by a rod-like appearance, as well as meningeal CAA identified as open circles on top of the cortex. b Adu, whether administered with or without SUS, had no effect on the number of CAA-affected vessels, average size, or percent area occupied by CAA. c Adu, whether administered by itself or with SUS, had no effect on the number of microhemorrhages detected by Prussian blue staining in 22-month old APP23 mice. Data are represented as mean ± SEM. Statistical differences: *p < 0.05. Data were analyzed with a one-way ANOVA and t test. Scale bar 200 μm