From: Early detection of amyloid load using 18F-florbetaben PET
Method | Region | SUVReHC | SUVRAD | SUVRcutoff | Sensitivity | Specificity | AUC |
---|---|---|---|---|---|---|---|
MRI-based ROIs | Frontal | 1.15 ± 0.07 | 1.57 ± 0.19 | 1.31 | 95% | 97% | 0.98 |
Lateral temporal | 1.15 ± 0.05 | 1.51 ± 0.17 | 1.26 | 97% | 98% | 0.96 | |
Occipital | 1.20 ± 0.06 | 1.43 ± 0.16 | 1.29 | 88% | 95% | 0.94 | |
Parietal | 1.13 ± 0.08 | 1.51 ± 0.16 | 1.26 | 97% | 98% | 0.98 | |
Anterior cingulate | 1.28 ± 0.09 | 1.70 ± 0.22 | 1.43 | 92% | 97% | 0.98 | |
Posterior cingulate | 1.33 ± 0.09 | 1.77 ± 0.21 | 1.47 | 93% | 97% | 0.97 | |
Precuneus | 1.15 ± 0.08 | 1.60 ± 0.19 | 1.28 | 95% | 98% | 0.98 | |
Composite | 1.21 ± 0.06 | 1.58 ± 0.17 | 1.38 | 93% | 100% | 0.98 | |
CL ROIs | Cortex | 1.05 ± 0.06 6.8 ± 8.8 CL | 1.54 ± 0.22 81.0 ± 33.2 CL | 1.24 35.7 CL | 95% | 100% | 0.98 |