Early detection of amyloid load using 18F-florbetaben PET

Table 2 SUVRs of yHC (dataset #1, n = 65) and cutoffs for the detection of early Aβ accumulation (between parenthesis)

Method	Region	SUVR_yHC (cutoff)	p
MRI-derived ROIs	Frontal	1.09 ± 0.04 (1.16)	0.83
	Lateral temporal	1.09 ± 0.03 (1.15)	0.41
	Occipital	1.18 ± 0.04 (1.26)	0.93
	Parietal	1.12 ± 0.04 (1.20)	0.92
	Anterior cingulate	1.23 ± 0.07 (1.36)	0.13
	Posterior cingulate	1.28 ± 0.09 (1.45)	0.43
	Precuneus	1.12 ± 0.04 (1.21)	0.22
	Composite	1.16 ± 0.04 (1.25)	0.25
CL ROIs	Cortex	1.03 ± 0.03 (1.10) 2.82 ± 5.36 CL (13.54 CL)	0.32

yHC young healthy controls, SUVR_yHC SUVR (mean ± SD) of the young healthy controls, Aβ amyloid-beta, p p-values from the Shapiro-Wilk test to assess that SUVR values are normally distributed (p < 0.05 = significant differences from the normality)

ISSN: 1758-9193