Table 1 Candidate microRNA EV cargo
From: Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer’s disease
MicroRNA | Average miR expression (log scale) | Relevance to AD | Reference |
|---|---|---|---|
MiR-124-3p | 20,761.5 | Inhibition of neural inflammation in the damaged brain Downregulated in AD and neurodegenerative diseases | |
MiR-125b-5p | 22,278.9 | Normal expression attenuates Aβ-induced toxicity, reduces apoptosis and oxidative stress Regulates PSD-95 levels | |
MiR-125a-5p | 5284.8 | Downregulation decreases levels of PSD-95 in dendrites and dendrite complexity | [54] |
Neg control 1 | 726.0 | ||
Neg control 2 | 709.0 | ||
Neg control 3 | 688.5 | ||