27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial

Table 2 Intervention effect on 27-OH and impact of age, sex, ApoE4 carrier status, lipid-lowering medication, and change in total cholesterol

Factor	Difference between intervention and control		Randomization group x Factor interaction, p
Factor	N*	β (p)	Randomization group x Factor interaction, p
Age at baseline	< 70 years, N = 22	−0.51 (0.02)	0.01
Age at baseline	≥70 years, N = 22	0.21 (0.34)	0.01
Sex	Women, N = 20	− 0.06 (0.81)	0.52
Sex	Men, N = 24	−0.24 (0.26)	0.52
ApoE4 carrier status	No, N = 29	−0.13 (0.53)	0.96
ApoE4 carrier status	Yes, N = 14	−0.13 (0.65)	0.96
Lipid-lowering medication	No, N = 22	−0.13 (0.57)	0.77
Lipid-lowering medication	Yes, N = 22	−0.21 (0.34)	0.77
Change in total cholesterol	Decrease, N = 28	−0.19 (0.33)	0.43
Change in total cholesterol	No change/increase, N = 16	−0.18 (0.50)	0.43

Values are standardized β coefficients (p values) from linear regression models with change in 27-OH (difference between 2-year and baseline values) as a dependent variable. Differences between the intervention and control groups are shown from models with randomization group as an independent variable and stratified by each factor (age at baseline, sex, ApoE4 carrier status, lipid-lowering medication, or change in total cholesterol). p value for interaction shown from models including randomization group, factor (as continuous variable for age or total cholesterol change), and the randomization group x factor interaction. p values considered significant (bold) if < 0.05. *N: participants with available data from both baseline and 2-year follow-up for each analysis

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