Fig. 4
From: Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
Regional brain expression and tissue expression of representative proteins. a Clustering of RNA expression data showed brain region clustering of the forebrain and brainstem. Two clusters identified visually included genes with lower expression in the cerebellum compared to other brain regions and higher expression in brainstem regions compared to forebrain (Cluster 1). A few genes with lower expression in white matter-rich regions such and thalamus could also be identified (Cluster 2). b Distribution of RPH3A, AMPH and TNR in cerebral cortex, hippocampal formation and cerebellum from a healthy donor, as well as temporal cortex from two AD patients. The three selected proteins displayed a similar staining pattern in cerebral cortex as well as a general neuropil positivity in the AD tissue. Furthermore, TNR showed positive staining around the amyloid plaques