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Table 5 Adverse effects in weeks 6 and 12 for all randomized patients

From: Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease

Adverse effect Ketogenic diet (n = 26) Usual diet (n = 26)
Week 6 Week 12 Week 6 Week 12
Increased irritability 9 (35%) 5 (19%) 7 (27%) 9 (35%)
Increased fatigue 5 (19%) 6 (23%) 2 (8%) 7 (27%)
Sugar cravings 5 (19%) 2 (8%) 2 (8%) 6 (23%)
Insomnia 2 (8%) 1 (4%) 5 (19%) 5 (19%)
Muscle cramps 5 (19%) 3 (12%) 4 (15%) 1 (4%)
Constipation 4 (15%) 1 (4%) 2 (8%) 4 (15%)
Feeling lightheaded 1 (4%) 4 (15%) 2 (8%) 3 (12%)
Increased back pain 2 (8%) 1 (4%) 1 (4%) 3 (12%)
Excessive hunger 1 (4%) 2 (8%) 2 (8%) 0
Excessive thirst 3 (12%) 1 (4%) 1 (4%) 0
Nausea 2 (8%) 0 0 2 (8%)
Headache 1 (4%) 0 0 3 (12%)
Heartburn 2 (8%) 0 0 2 (8%)
Diarrhoea 1 (4%) 1 (4%) 0 0
Palpitations 0 1 (4%) 0 1 (4%)
Urinary calculus 0 0 0 1 (4%)
Gout flare-up 1 (4%) 0 0 0
Psychotic episode 0 0 0 1 (4%)
Total 44 28 28 48
  1. Regarding withdrawals, all adverse effects experienced up to the point of withdrawal are shown
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