Table 1 Baseline demographics and characteristics by diagnosis and medication class

 Follow-up time (years)

2.28 (1.48)

2.27 (1.51)

0.904

 Age (years)

77.2 (8.1)

76.8 (8.6)

0.377

 Female (%)

360 (62.3%)

533 (48.0%)

< 0.001

 Race (Caucasian)

468 (81.0%)

925 (83.3%)

0.240

 BMI (kg/m²)

27.5 (5.0)

27.1 (5.0)

0.128

 Education (years)

14.3 (3.5)

14.2 (3.6)

0.577

 Smoking history (years)

11.4 (16.6)

10.6 (16.4)

0.342

 Systolic BP (mmHg)

139.0 (20.2)

137.8 (20.4)

0.269

 Diastolic BP (mmHg)

75.6 (11.2)

74.3 (11.0)

0.019

 MMSE

22.5 (4.9)

21.8 (5.4)

0.004

 APOE ε4 carrier

311 (53.8%)

648 (58.3%)

0.075

 AD medication use

396 (68.5%)

738 (66.4%)

0.387

 Hypercholesterolemia

376 (65.1%)

727 (65.6%)

0.818

 Hypertension

549 (95.0%)

1025 (92.3%)

0.112

 Stroke/TIA history

87 (15.1%)

148 (13.3%)

0.330

 Heart failure

29 (5.0%)

43 (3.9%)

0.268

 Myocardial infarct

43 (7.5%)

120 (10.8%)

0.026

 Diabetes

131 (22.7%)

264 (23.8%)

0.613

 Depression

246 (42.6%)

408 (36.7%)

0.019

 β-Blockers

140 (24.2%)

308 (27.7%)

0.122

 CCBs

166 (28.7%)

267 (24.0%)

0.036

 DRTCs

220 (38.1%)

370 (33.3%)

0.052

 Statins

338 (58.5%)

694 (62.5%)

0.111

 Antidepressants

216 (37.4%)

407 (36.6%)

0.766

 NSAIDs

262 (45.3%)

508 (45.7%)

0.877