Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits

Table 2 AD-centric analysis pleiotropic loci

Cardiometabolic trait	Locus name	Lead SNP	Chr	Position GRCh37	Effect allele/other allele	Direction of effect AD/CM	Effect allele frequency	Bivariate P value	AD P value	Cardiometabolic trait P value	Conditional posterior probability of colocalization	Cardiometabolic GWAS
DBP	ADAM10	rs442495	15	59022615	T/C	+/+	0.65	1.98e−10	1.31e−09	9.71e−05	0.88	Evangelou et al. [20]
WHRadjBMI	ADAMTS4	rs4575098	1	161155392	A/G	+/+	0.22	4.45e−13	2.05e−10	1.99e−06	0.87	Pulit et al. [22]
DBP	ACE	rs4308	17	61559625	G/A	+/−	0.63	7.05e−15	8.52e−07	1.00e−16	0.98	Evangelou et al. [20]
SBP	ACE	rs4308	17	61559625	G/A	+/−	0.63	8.01e−15	8.52e−07	1.00e−16	0.98	Evangelou et al. [20]

Chr chromosome of the SNP. Direction of effect first position is the direction of effect of the effect allele on AD and the cardiometabolic trait. Effect allele frequency from the Jansen et al. [17] allele frequency. Conditional posterior probability of colocalization, PP4/ (PP3 + PP4) the results of the trait-trait colocalization analysis

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