Fig. 2
Association of mGluR5 binding ([18F]FPEB BPND) in the hippocampus with Clinical Dementia Rating (CDR) sum of boxes and episodic memory. Reduced hippocampal mGluR5 binding was associated with more severe disease (r = − 0.53, p = 0.002) measured by CDR sum of boxes (a) and lower composite episodic memory scores (b) (r = 0.40, p = 0.027) in the overall sample. Episodic memory performance is the average of z-scores for CVLT free delayed recall and Logical Memory II. The figure displays linear regression line with its 95% confidence interval. CDR, Clinical Dementia Rating