Fig. 1

Chronic JM4 treatment reduced neurological deficit and prolonged lifespan in PS19 mice. a In a cohort of mice in which JM4 treatment was initiated at 2 months of age, the PBS sham-treated PS19 mice (open circles) showed an earlier onset of disease than the JM4-treated PS19 mice (filled circles). Disease onset was defined as the age at which mice displayed clasping of at least one hind limb for 30 s when suspended by their tail (clinical score 2) (p = 0.03, log rank (Mantel-Cox) test). b Kaplan-Meier curves show that JM4 treatment (black line) prolongs lifespan of PS19 mice compared to PBS sham-treatment (red line) (p = 0.02, log rank (Mantel-Cox) test). c In another cohort of mice in which JM4 treatment was initiated at one month of age, JM4-treated PS19 mice (filled squares) display less severe neurological deficit compared to PBS sham-treated PS19 mice (open circles) from 5.5 months and on (*p < 0.05, **p < 0.01, two-tailed unpaired t test for each time point)