Subjects (N = 2603) | Events (N = 928) | Deaths (N = 45) | Unadjusted RR | Unadj. p value | Adjusted RR | Adj. p value | |
---|---|---|---|---|---|---|---|
Partner typea | 0.57 | 0.954 | |||||
Spouse | 1721 | 569 | 28 | 1 | – | 1 | – |
Adult child | 658 | 235 | 16 | 1.20 (1.03, 1.40) | 0.018 | 1.03 (0.76, 1.39) | 0.837 |
Other | 224 | 79 | 1 | 1.12 (0.88, 1.41) | 0.356 | 1.05 (0.77, 1.44) | 0.756 |
Participant age (per 10 years) | 2603 | 883 | 45 | 1.37 (1.26, 1.49) | < .001 | 1.37 (1.22, 1.54) | < .001 |
Education (years) | 2603 | 883 | 45 | 0.98 (0.97, 1.00) | 0.016 | 0.99 (0.97, 1.01) | 0.205 |
Partner age (per 10 years) | 2603 | 883 | 45 | 1.04 (0.98, 1.09) | 0.188 | 1.02 (0.93, 1.13) | 0.623 |
Baseline test scores | |||||||
Mini-Mental State Exam | 2603 | 883 | 45 | 0.94 (0.92, 0.96) | < .001 | 0.95 (0.93, 0.97) | < .001 |
Hachinski Score | 2603 | 883 | 45 | 1.12 (1.05, 1.21) | 0.001 | 1.02 (0.95, 1.10) | 0.586 |
Geriatric Depression Scale | 2603 | 883 | 45 | 1.10 (1.05, 1.14) | < .001 | 1.10 (1.05, 1.15) | < .001 |
Participant sex | |||||||
Female | 1437 | 474 | 19 | 1 | – | 1 | – |
Male | 1166 | 409 | 26 | 1.05 (0.92, 1.20) | 0.471 | 1.18 (0.98, 1.42) | 0.085 |
Partner sex | |||||||
Female | 1602 | 562 | 26 | 1 | – | 1 | – |
Male | 1001 | 321 | 19 | 0.90 (0.78, 1.03) | 0.135 | 1.04 (0.86, 1.25) | 0.684 |
Partner employed | |||||||
No | 1652 | 588 | 27 | 1 | – | 1 | – |
Yes | 951 | 295 | 18 | 0.87 (0.75, 0.99) | 0.042 | 0.91 (0.77, 1.07) | 0.251 |
APOE carrier | |||||||
No | 903 | 313 | 20 | 1 | – | 1 | – |
Yes | 1700 | 570 | 25 | 0.96 (0.84, 1.10) | 0.580 | 1.02 (0.88, 1.17) | 0.821 |
Region | |||||||
North America | 971 | 350 | 19 | 1 | – | 1 | – |
South America/Mexico | 201 | 75 | 6 | 1.20 (0.94, 1.53) | 0.146 | 1.00 (0.76, 1.31) | 0.981 |
Eastern Europe/Russia | 286 | 131 | 2 | 1.55 (1.27, 1.89) | < .001 | 1.49 (1.19, 1.87) | < .001 |
Western Europe/Israel | 543 | 160 | 7 | 0.79 (0.65, 0.95) | 0.012 | 0.82 (0.67, 1.00) | 0.049 |
Australia/South Africa | 151 | 51 | 6 | 0.91 (0.68, 1.23) | 0.537 | 0.91 (0.67, 1.23) | 0.525 |
Asia | 200 | 60 | 2 | 1.08 (0.82, 1.42) | 0.567 | 1.03 (0.77, 1.37) | 0.854 |
Japan | 251 | 56 | 3 | 0.60 (0.45, 0.79) | < .001 | 0.58 (0.43, 0.78) | < .001 |