Skip to main content

Table 3 Sensitivity analysis—estimated relative risk (RR) for the risk of dropout when censoring participants who died

From: Recruitment and retention of participant and study partner dyads in two multinational Alzheimer’s disease registration trials

 

Subjects (N = 2603)

Events (N = 928)

Deaths (N = 45)

Unadjusted RR

Unadj. p value

Adjusted RR

Adj. p value

Partner typea

    

0.57

 

0.954

 Spouse

1721

569

28

1

1

 Adult child

658

235

16

1.20 (1.03, 1.40)

0.018

1.03 (0.76, 1.39)

0.837

 Other

224

79

1

1.12 (0.88, 1.41)

0.356

1.05 (0.77, 1.44)

0.756

Participant age (per 10 years)

2603

883

45

1.37 (1.26, 1.49)

< .001

1.37 (1.22, 1.54)

< .001

Education (years)

2603

883

45

0.98 (0.97, 1.00)

0.016

0.99 (0.97, 1.01)

0.205

Partner age (per 10 years)

2603

883

45

1.04 (0.98, 1.09)

0.188

1.02 (0.93, 1.13)

0.623

Baseline test scores

 Mini-Mental State Exam

2603

883

45

0.94 (0.92, 0.96)

< .001

0.95 (0.93, 0.97)

< .001

 Hachinski Score

2603

883

45

1.12 (1.05, 1.21)

0.001

1.02 (0.95, 1.10)

0.586

 Geriatric Depression Scale

2603

883

45

1.10 (1.05, 1.14)

< .001

1.10 (1.05, 1.15)

< .001

Participant sex

 Female

1437

474

19

1

1

 Male

1166

409

26

1.05 (0.92, 1.20)

0.471

1.18 (0.98, 1.42)

0.085

Partner sex

 Female

1602

562

26

1

1

 Male

1001

321

19

0.90 (0.78, 1.03)

0.135

1.04 (0.86, 1.25)

0.684

Partner employed

 No

1652

588

27

1

1

 Yes

951

295

18

0.87 (0.75, 0.99)

0.042

0.91 (0.77, 1.07)

0.251

APOE carrier

 No

903

313

20

1

1

 Yes

1700

570

25

0.96 (0.84, 1.10)

0.580

1.02 (0.88, 1.17)

0.821

Region

 North America

971

350

19

1

1

 South America/Mexico

201

75

6

1.20 (0.94, 1.53)

0.146

1.00 (0.76, 1.31)

0.981

 Eastern Europe/Russia

286

131

2

1.55 (1.27, 1.89)

< .001

1.49 (1.19, 1.87)

< .001

 Western Europe/Israel

543

160

7

0.79 (0.65, 0.95)

0.012

0.82 (0.67, 1.00)

0.049

 Australia/South Africa

151

51

6

0.91 (0.68, 1.23)

0.537

0.91 (0.67, 1.23)

0.525

 Asia

200

60

2

1.08 (0.82, 1.42)

0.567

1.03 (0.77, 1.37)

0.854

 Japan

251

56

3

0.60 (0.45, 0.79)

< .001

0.58 (0.43, 0.78)

< .001

  1. aPartial likelihood ratio test of the null hypothesis that there is no difference in risk of dropping out by study partner (SP) type