Fig. 5
From: Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice
Immunohistochemical analysis of Aβ burden in hippocampus of APP/PS1 mice. a Representative images of 6E10-labeled Aβ burden in the ipsilateral and contralateral hippocampus of APP/PS1 mice. Scale bars, 200 μm. b, c Quantification of percent area covered by 6E10 staining in the ipsilateral hippocampus (hpx) (b) and contralateral hippocampus (c) of the APP/PS1 mice. d–i Quantification of percent area covered by 6E10 staining in the ipsilateral DG (d), CA3 (f), CA1 (h), contralateral DG (e), CA3 (g), and CA1 (i) of the hippocampi of APP/PS1 mice. Data were analyzed by one-way ANOVA followed by the Bonferroni post hoc test. Values are presented as mean±SEM. n = 5 per group. *P < 0.05 vs. ctr+veh group; #P < 0.05 vs. tau+veh group; &P < 0.05 vs. ctr+met group