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Table 2 Comparison of AD-RAI and volumetric brain measures among NC, AD, and FTD groups from NACC

From: An MRI-based strategy for differentiation of frontotemporal dementia and Alzheimer’s disease

  NC (n = 47) AD (n = 47) FTD (n = 47) p value
NC vs AD NC vs FTD AD vs FTD
AD-RAI 0.12 (0.20) 0.94 (0.51) 0.97 (0.23) < 0.001 < 0.001 0.647
Hippocampus 0.45 (0.05) 0.39 (0.09) 0.42 (0.07) < 0.001 0.446 0.008
Caudate (L) 0.23 (0.02) 0.23 (0.04) 0.21 (0.04) 0.491 0.836 0.040
Frontal lobe (L) atrophy 42.50 (14.40) 42.30 (13.30) 51.30 (14.10) > 0.999 < 0.001 0.002
Frontal lobe (R) atrophy 40.70 (14.80) 43.40 (12.80) 51.50 (15.30) 0.647 < 0.001 0.001
Occipital lobe (R) atrophy 9.11 (4.82) 12.70 (5.90) 10.00 (5.46) < 0.001 > 0.999 < 0.001
Frontal lobe (L) 5.56 (0.67) 5.50 (0.51) 5.22 (0.65) > 0.999 0.001 0.022
Occipital lobe (R) 2.26 (0.31) 2.13 (0.52) 2.36 (0.34) > 0.999 0.150 0.022
Temporal lobe (L) 3.71 (0.32) 3.30 (0.40) 3.06 (0.76) < 0.001 < 0.001 0.061
Temporal lobe (R) 3.68 (0.37) 3.30 (0.55) 3.20 (0.71) < 0.001 < 0.001 0.540
Parietal lobe (L) 2.63 (0.31) 2.42 (0.38) 2.63 (0.38) < 0.001 > 0.999 < 0.001
Parietal lobe (R) 2.81 (0.42) 2.50 (0.37) 2.86 (0.40) 0.005 0.239 < 0.001
Insular (L) 0.47 (0.05) 0.42 (0.05) 0.36 (0.07) 0.239 < 0.001 < 0.001
Insular (R) 0.48 (0.05) 0.46 (0.05) 0.42 (0.09) 0.103 < 0.001 0.012
QMTA 0.33 (0.07) 0.55 (0.32) 0.52 (0.38) < 0.001 < 0.001 > 0.999
MTA score 0.25 (1.00) 1.50 (1.50) 1.50 (1.50) < 0.001 < 0.001 > 0.999
  1. The comparison was performed with Friedman M test and a post hoc analysis with Wilcoxon signed-rank test with Bonferroni correction. p value would be highlighted in bold when it was below 0.05. The median with inter-quartile range (in bracket) of AD-RAI and the volumetric brain measures in all three groups were provided. L left, R right