Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J

Table 1 Participant demographics and test results

	Cognitively normal	Mild cognitive impairment	Mild dementia	F/χ²	P
Participants (n)	19	14	24
Sex (M/F)	9/10	9/5	9/15	2.55	0.28
Age (years)	71.5 (7.6)	71.6 (4.2)	69.9 (9.2)	0.30	0.74
Education (years)	17.7 (2.1)	17.3 (1.9)	15.8 (2.4)*	4.71	0.013
CDR-global	0 (0)	0.5 (0)***	0.88 (0.22)***^,†††	194.90	< 0.0001
CDR-SB	0 (0)	2.32 (1.03)***	5.25 (1.52) ***^,†††	119.72	< 0.0001
GDS	0.68 (0.82)	2.79 (2.15)*	1.50 (1.84)	6.40	0.003
UPSIT	34.05 (5.86)	22.64 (9.79)**	21.09 (6.95)***	17.35	< 0.0001
MMSE	29.21 (1.13)	26.29 (2.89)*	21.46 (2.98)***^,†††	52.88	< 0.0001
LMII	13.58 (4.38)	3.57 (2.98)***	0.25 (0.44)***^,†	113.55	< 0.0001
RAVLT-delay	11.05 (2.80)	2.14 (2.71)***	0.29 (0.69)***^,†	143.61	< 0.0001
Episodic memory (z-score)	1.25 (0.52)	−0.35 (0.39)***	−0.78 (0.08)***^,†	177.54	< 0.0001
*APOE* ɛ4 copy number (n)				14.95	0.005
2 copies	0 (0%)	5 (35.7%)	5 (20.8%)
1 copy	4 (21.1%)	4 (28.6%)	12 (50.0%)
0 copies	15 (78.9%)	5 (35.7%)	7 (29.2%)

Data for continuous variables are mean (SD). Data for APOE copy number are n (percent). F statistics and P values are from one-way ANOVA significance tests. χ² statistics and P values for counts are from χ² significance tests. Post hoc unpaired t-tests after one-way ANOVA for continuous variables were Bonferroni corrected for 3 diagnostic groups. * denotes significant group differences between either amnestic mild cognitive impairment and cognitively normal or mild dementia and cognitively normal. * P < 0.05, ** P < 0.001, *** P < 0.0001. † denotes significant group differences between mild dementia and amnestic mild cognitive impairment. † P < 0.05, †† P < 0.001, ††† P < 0.0001. Episodic Memory was calculated by averaging the z-scores of the RAVLT and LMII. Abbreviations: CDR-global clinical dementia rating global score, CDR-SB clinical dementia rating sub of boxes, MMSE Mini-Mental State Examination, LMII Logical Memory II score, RAVLT Rey Auditory Verbal Learning Test, GDS Geriatric Depression Scale, UPSIT University of Pennsylvania Smell Identification Test, APOE Apolipoprotein E

ISSN: 1758-9193