Fig. 1

Comparison of SV2A and Aβ deposition in CN, aMCI, and dementia groups. Coronal sections of average parametric images of DVR for a [¹¹C]UCB-J and b [¹¹C] PiB in CN, aMCI, and dementia groups. Averaged images were created after co-registration to a common MNI template and overlaid on an MNI template T1 MRI. Parametric images adhere to radiological convention, with orientation denoted in the first coronal section of each image series. Quantification of between-group differences in c [¹¹C]UCB-J DVR and d [¹¹C] PiB DVR across all ROIs. One-way ANOVAs within each ROI with post hoc unpaired t-tests, FDR-corrected for multiple comparisons (3 comparisons for diagnostic groups), demonstrated significantly lower [¹¹C]UCB-J DVR and significantly higher [¹¹C] PiB DVR in both the aMCI and dementia participants (as compared to CN) across most analyzed regions. No group differences were observed in either SV2A or Aβ binding between aMCI and dementia participants across all analyzed ROIs. # denotes significant post hoc group differences between aMCI and CN. # P < 0.05, ## P < 0.001, ### P < 0.0001. * denotes significant group post hoc differences between dementia and CN. * P < 0.05, ** P < 0.001, *** P < 0.0001. Abbreviations: DVR, distribution volume ratio using a whole cerebellum reference region; PCC, posterior cingulate cortex, aMCI: amnestic mild cognitive impairment; CN: cognitively normal; MNI, Montreal Neurological Institute; MRI, magnetic resonance image; PET, positron emission tomography; ROI, region of interest; SV2A, synaptic vesicle glycoprotein 2A; PiB, Pittsburgh Compound B; FDR, false discovery rate