Table 3 Summary of Kruskal-Wallis univariate analysis
Metabolite | p value (Kruskal-Wallis test) | Adjusted p value (Holm) | Dunn’s post hoc test p value | ||
|---|---|---|---|---|---|
CTL-AD | CTL-MCI | MCI-AD | |||
Urine—xanthurenic acid | 0.0002 | 0.0015 | 0.0001 | 0.0016 | 0.1615 |
Urine—kynurenic acid | 0.0009 | 0.0071 | 0.0005 | 0.0047 | 0.181 |
Urine—serotonin | 0.0020 | 0.0137 | 0.0016 | 0.2724 | 0.0047 |
Urine—5-hydroxyindoleacetic acid | 0.0059 | 0.0293 | 0.0020 | 0.0842 | 0.0517 |
Urine—tryptophan | 0.0128 | 0.0514 | 0.0050 | 0.098 | 0.0748 |
Urine—3-hydroxyanthranilic acid | 0.0495 | 0.1484 | NA | NA | NA |
Urine—3-hydroxykynurenine | 0.4235 | 0.8470 | NA | NA | NA |
Urine—kynurenine | 0.8738 | 0.8738 | NA | NA | NA |
Urine—kynurenine/tryptophan ratio | 0.0040 | 0.0242 | 0.0021 | 0.0138 | 0.1966 |
Serum—xanthurenic acid | 0.0018 | 0.0339 | 0.0019 | 0.0260 | 0.2796 |
Serum—kynurenine | 0.0019 | 0.0339 | 0.0006 | 0.0429 | 0.0286 |
Serum—serotonin | 0.0037 | 0.0625 | 0.0016 | 0.0178 | 0.1035 |
Serum—tryptophan | 0.0047 | 0.0756 | 0.0024 | 0.0150 | 0.1407 |
Serum—3-hydroxyanthranilic acid | 0.0222 | 0.3326 | NA | NA | NA |
Serum—kynurenic acid | 0.0222 | 0.3326 | NA | NA | NA |
Serum—3-hydroxykynurenine | 0.0236 | 0.3326 | NA | NA | NA |
Serum—β-nicotinamide mononucleotide | 0.0241 | 0.3326 | NA | NA | NA |
Serum—picolinic acid | 0.0518 | 0.5701 | NA | NA | NA |
Serum—5-hydroxyindoleacetic acid | 0.0991 | 0.9912 | NA | NA | NA |
Serum—nicotinic acid | 0.1066 | 0.9912 | NA | NA | NA |
Serum—quinolinic acid | 0.1828 | 1.0000 | NA | NA | NA |
Serum—NAD+ | 0.2589 | 1.0000 | NA | NA | NA |
Serum—dopamine | 0.3926 | 1.0000 | NA | NA | NA |
Serum—neopterin | 0.4934 | 1.0000 | NA | NA | NA |
Serum—nicotinic riboside | 0.6746 | 1.0000 | NA | NA | NA |
Serum citrulline | 0.8351 | 1.0000 | NA | NA | NA |
Serum—indole-3-acetic acid | 0.8518 | 1.0000 | NA | NA | NA |
Serum—kynurenine/tryptophan ratio | 0.2507 | 1.0000 | NA | NA | NA |