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Table 1 Demographic and clinical characteristics of the participants

From: Smaller pineal gland is associated with rapid eye movement sleep behavior disorder in Alzheimer’s disease

 

Without pRBD (n = 257)

With pRBD (n = 39)

p

Age (years, mean ± SD)

77.4 ± 7.4

76.8 ± 7.4

0.634a

Sex (women, %)

69.3

79.5

0.191a

Education (years, mean ± SD)

9.9 ± 5.6

8.1 ± 5.5

0.065a

Presence of cohabitants, (present, %)

80.5

74.4

0.371a

Duration of AD (months, mean ± SD)

36.9 ± 25.7

44.0 ± 37.8

0.265a

Drugs influencing sleep or motor activity (users, %)

29.2

38.5

0.240a

History of head injury (present, %)

9.0

10.3

0.792a

Alcohol drinking (SU/week, mean ± SD)

1.8 ± 7.1

0.7 ± 3.4

0.375a

Smoking (packs/day, mean ± SD)

0.1 ± 0.6

0.0 ± 0.2

0.750a

GDS (points, mean ± SD)

12.2 ± 6.9

16.5 ± 6.7

< 0.001a

CDR (points, mean ± SD)

0.7 ± 0.4

0.9 ± 0.5

0.903a

STOP-BANG (points, mean ± SD)

2.3 ± 0.9

2.6 ± 1.0

0.041a

RBDSQ (points, mean ± SD)

 Total score

1.4 ± 1.2

6.1 ± 1.4

< 0.001a

 Item-6 score

0.2 ± 0.5

1.2 ± 1.2

< 0.001a

Intracranial volume (cm3, mean ± SD)

1515.5 ± 147.7

1509.1 ± 154.1

0.805a

VPP (mm3, mean ± SD)

69.5 ± 18.5

51.7 ± 10.8

< 0.001b

Cerebral amyloid deposition (present, %)

31.9

28.2

0.643a

  1. Abbreviations: pRBD probable REM sleep behavior disorder, SD standard deviation, AD Alzheimer’s disease, SU standard units, GDS Geriatric Depression Scale, CDR Clinical Dementia Rating, RBDSQ REM Sleep Behavior Disorder Screening Questionnaire, VPP pineal parenchyma volume
  2. aIndependent sample t test for continuous variables and chi-square test for categorical variables
  3. bAnalysis of covariance adjusted for age, sex, years of education, intracranial volume, head injury, amount of smoking, amount of alcohol drinking, and use of drugs influencing sleep or motor activity