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Table 3 Multivariate analysis of perfusion density of large vessels and foveal avascular zone with cognitive impairment

From: Retinal microvasculature dysfunction is associated with Alzheimer’s disease and mild cognitive impairment

Cognitive status Superficial capillary plexus Deep capillary plexus
Mean ± SD β 95 CI P value* Mean ± SD β 95 CI P value*
Perfusion density of large vessels (%)
 Control 6.92 ± 1.16 Reference   
 MCI 6.39 ± 1.27 − 0.53 − 1.15 to 0.09 0.091
 AD 7.02 ± 1.29 0.10 − 0.61 to 0.81 0.787
Foveal avascular zone area (mm2)
 Control 0.31 ± 0.12 Reference 1.11 ± 0.47 Reference
 MCI 0.35 ± 0.12 0.041 − 0.02 to 0.10 0.190 1.24 ± 0.39 0.129 − 0.07 to 0.33 0.197
 AD 0.34 ± 0.14 0.034 − 0.04 to 0.11 0.380 1.13 ± 0.43 0.016 − 0.23 to 0.26 0.898
  1. AD Alzheimer’s disease, CI confidence intervals, MCI mild cognitive impairment, SD standard deviation
  2. *Adjusted for age, gender, race, diabetes, blood pressure (systolic and diastolic levels), and signal strength of OCTA scans