|
Characteristics
|
AD (n = 24)
|
MCI (n = 37)
|
Control (n = 29)
|
P value*
|
|---|
|
Age
|
74.9 ± 6.0
|
77.9 ± 6.4
|
76.7 ± 5.3
|
0.176
|
|
Gender, female
|
17 (73)
|
16 (44)
|
13 (45)
|
0.082
|
|
Race, Chinese
|
16 (84)
|
30 (82)
|
23 (79)
|
0.082
|
|
Diabetes, yes
|
9 (41)
|
10 (32)
|
4 (14)
|
0.039
|
|
Hypertension, yes
|
15 (78)
|
21 (62)
|
17 (59)
|
0.319
|
|
Systolic blood pressure, mmHg
|
148 ± 11
|
139 ± 18
|
131 ± 16
|
0.008
|
|
Diastolic blood pressure, mmHg
|
73 ± 9
|
70 ± 9
|
70 ± 8
|
0.363
|
|
MMSE
|
20.3 ± 6.1
|
23.9 ± 6.3
|
24.8 ± 4.8
|
0.026
|
|
Neuroimaging markers
|
|
MTA scores
|
1.3 ± 0.7
|
1.4 ± 0.8
|
1.7 ± 0.7
|
0.297
|
|
GCA scores
|
1.5 ± 0.6
|
1.6 ± 0.6
|
2.3 ± 0.8
|
0.006
|
|
WMH scores
|
1.6 ± 0.7
|
1.5 ± 0.7
|
2.1 ± 0.7
|
0.098
|
|
Signal strength, out of 10
|
9.8 ± 0.8
|
9.8 ± 0.5
|
9.6 ± 0.7
|
0.010
|
- Data presented are mean (SD) or number (%), as appropriate
- AD Alzheimer’s disease, MCI mild cognitive impairment, MMSE Mini-Mental State Exam, MTA medial temporal atrophy, GCA global cortical atrophy, WMH white matter hyperintensities
- *P value was obtained with ANOVA for the continuous variables and with chi-square tests for categorical variables
