Table 2 Effects of common APOE SNVs on imaging biomarkers and conditional analysis of the SNVs controlling for each imaging biomarkers
From: Genetic associations of in vivo pathology influence Alzheimer’s disease susceptibility
APOE SNP | Imaging biomarkers | Association (Quant.) | Cognitive function association | |||
|---|---|---|---|---|---|---|
β | P | Padj | Unconditioned | Controlling for imaging biomarker (Quant.) | ||
rs429358 (chr19:45411941) | Aβ deposition | 0.37 | 2.85 × 10−27 | 2.89 × 10−24 | 2.03 × 10−9 | 0.047 |
AD-Cm | − 0.06 | 5.61 × 10−6 | 2.85 × 10−3 | 2.18 × 10−5 | ||
PCC-Cm | − 0.10 | 3.07 × 10−10 | 3.12 × 10−7 | 3.16 × 10−3 | ||
AD-Ct | − 0.11 | 8.70 × 10−13 | 8.80 × 10−10 | 2.82 × 10−3 | ||
Hv | − 0.78 | 2.23 × 10−18 | 2.25 × 10−15 | 0.150 | ||
rs769449 (chr19:45410002) | Aβ deposition | 0.39 | 1.51 × 10−25 | 7.65 × 10−23 | 7.29 × 10−8 | 0.260 |
AD-Cm | − 0.06 | 2.78 × 10−6 | 2.82 × 10−3 | 3.08 × 10−3 | ||
PCC-Cm | − 0.10 | 8.58 × 10−9 | 4.36 × 10−6 | 0.052 | ||
AD-Ct | − 0.11 | 2.16 × 10−9 | 1.09 × 10−6 | 0.022 | ||
Hv | − 0.73 | 3.72 × 10−13 | 1.88 × 10−10 | 0.210 | ||
rs405509 (chr19:45408836) | Aβ deposition | − 0.09 | 5.78 × 10−3 | 0.84 | 1.94 × 10−3 | 0.020 |
AD-Cm | 0.03 | 3.15 × 10−3 | 0.40 | 0.029 | ||
PCC-Cm | 0.03 | 0.017 | 0.83 | 0.032 | ||
AD-Ct | 0.02 | 0.16 | 0.99 | 0.011 | ||
Hv | 0.14 | 0.089 | 0.96 | 0.017 | ||