Skip to main content

Table 2 Effects of common APOE SNVs on imaging biomarkers and conditional analysis of the SNVs controlling for each imaging biomarkers

From: Genetic associations of in vivo pathology influence Alzheimer’s disease susceptibility

APOE SNP Imaging biomarkers Association (Quant.) Cognitive function association
β P Padj Unconditioned Controlling for imaging biomarker (Quant.)
rs429358 (chr19:45411941) Aβ deposition 0.37 2.85 × 10−27 2.89 × 10−24 2.03 × 10−9 0.047
AD-Cm − 0.06 5.61 × 10−6 2.85 × 10−3 2.18 × 10−5
PCC-Cm − 0.10 3.07 × 10−10 3.12 × 10−7 3.16 × 10−3
AD-Ct − 0.11 8.70 × 10−13 8.80 × 10−10 2.82 × 10−3
Hv − 0.78 2.23 × 10−18 2.25 × 10−15 0.150
rs769449 (chr19:45410002) Aβ deposition 0.39 1.51 × 10−25 7.65 × 10−23 7.29 × 10−8 0.260
AD-Cm − 0.06 2.78 × 10−6 2.82 × 10−3 3.08 × 10−3
PCC-Cm − 0.10 8.58 × 10−9 4.36 × 10−6 0.052
AD-Ct − 0.11 2.16 × 10−9 1.09 × 10−6 0.022
Hv − 0.73 3.72 × 10−13 1.88 × 10−10 0.210
rs405509 (chr19:45408836) Aβ deposition − 0.09 5.78 × 10−3 0.84 1.94 × 10−3 0.020
AD-Cm 0.03 3.15 × 10−3 0.40 0.029
PCC-Cm 0.03 0.017 0.83 0.032
AD-Ct 0.02 0.16 0.99 0.011
Hv 0.14 0.089 0.96 0.017