Fig. 8

Morris water maze test of mice treated weekly for 38 weeks with 12 mg/kg K11_IgG2a, 3D6_IgG2a, and isotype control. Learning curves were obtained by delineation of the average trial time for 4 trials per day at days 1–4. Antibody-treated 5xFAD groups are compared to wild-type animals treated with 12 mg/kg isotype control. Test animals were placed in a circular pool and are required to find an invisible platform that allows them to escape the water. The circular pool is divided into 4 equal quadrants. Test animals were placed into the first quadrant and time was counted until they reached the platform. After at least 5-min pause, test animals were placed into the second quadrant and exposed to the same procedure. The animals were allowed to pause again, followed by putting them in quadrant 3, followed by another pause and putting them again in quadrant 2. At the end, time until the test animals reached the platform was analyzed for every mouse in 4 trials per day. The error bars represent SEM