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Table 1 Clinical characteristics of the discovery and validation cohorts

From: Prognosis prediction model for conversion from mild cognitive impairment to Alzheimer’s disease created by integrative analysis of multi-omics data

Phenotype

Factor

All

Discovery cohort

Validation cohort

MCI-C

Number of subjects

83

41

42

Age ± SD

75.22 ± 6.22

75.10 ± 5.64

75.33 ± 6.81

Percentage of male (# patients)

29 (24)

41 (17)

17 (7)

Number of APOE4 alleles (# patients)

0 (46), 1 (29), 2 (8)

0 (25), 1 (13), 2 (3)

0 (21), 1 (16), 2 (5)

Follow-up, mean ± SD (days)

927.18 ± 535.03

1014.07 ± 593.22

842.36 ± 462.90

MCI-NC

Number of subjects

114

57

57

Age ± SD

75.56 ± 6.39

75.42 ± 5.75

75.70 ± 7.02

Percentage of male (# patients)

43 (49)

44 (25)

42 (24)

Number of APOE4 alleles (# patients)

0 (80), 1 (32), 2 (2)

0 (40), 1 (15), 2 (2)

0 (40), 1 (17), 2 (0)

Follow-up, mean ± SD (days)

1002.23 ± 564.49

939.70 ± 554.31

1064.75 ± 572.52

Total subjects

197

98

99

  1. MCI-C mild cognitive impairment converters (to Alzheimer’s disease), MCI-NC mild cognitive impairment non-converters, SD standard deviation