|
Parameter
|
Alzheimer’s disease (AD) patients (n = 17)
|
Controls (n = 22)
|
P
|
|---|
|
Time since AD diagnosis (years)
|
2.7 ± 2.6
|
NA
|
–
|
|
Age (years)
|
71.9 ± 6.6
|
68.6 ± 8.4
|
0.193*
|
|
Sex (male/female)
|
7/10
|
12/9
|
0.267‡
|
|
Body mass index (kg/m2)
|
24.9 ± 2.9
|
26.0 ± 4.4
|
0.412*
|
|
Eye (right/left)
|
10/7
|
10/12
|
0.408‡
|
|
MMSE
|
17.6 ± 5.5
|
29.3 ± 0.9
|
< 0.001†
|
|
BCVA (logMAR)
|
0.14 ± 0.11
|
0.06 ± 0.08
|
0.027*
|
|
IOP (mmHg)
|
14 ± 3
|
15 ± 4
|
0.359*
|
|
Phakic (yes/no)
|
15/2
|
12/10
|
0.024‡
|
|
Vertical cup/disc ratio
|
0.52 ± 0.15
|
0.51 ± 0.21
|
0.878*
|
|
RNFLAVG (μm)
|
84.8 ± 7.5
|
92.1 ± 7.3
|
0.005§
|
|
RNFLSUP (μm)
|
104.2 ± 8.9
|
109.8 ± 12.4
|
0.019§
|
|
RNFLINF (μm)
|
104.3 ± 11.1
|
115.6 ± 11.4
|
0.009§
|
|
RNFLTEM (μm)
|
63.3 ± 8.1
|
70.4 ± 6.7
|
0.069§
|
|
RNFLNAS (μm)
|
66.3 ± 11.7
|
72.7 ± 8.6
|
0.012§
|
- MMSE Mini-Mental State Examination, BCVA best corrected visual acuity, RNFL retinal nerve fiber layer. Data are presented as mean ± standard deviation
- *Independent samples t test
- †Mann-Whitney U test
- ‡Chi-square test
- §Multivariate linear regression corrected for age, gender, and image quality
