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Table 5 Tau subgroup comparisons on MMSE at first visit and annual change rates

From: Four subgroups based on tau levels in Alzheimer’s disease observed in two independent cohorts

 

Subgroup effect

Baseline estimated marginal means ± SE of subgroup

p values of pairwise comparisons between subgroups

Time effect

Subgroup x Time

Estimated slopes ± SE of subgroup

p value of pairwise comparisons of slope differences between subgroups

Bio-marker

Cognitive state

Cohort: platform

N per subgroup

1/2/3/4

p value

Subgroup 1

Subgroup 2

Subgroup 3

Subgroup 4

1 vs 2

1 vs 3

1 vs 4

2 vs 3

2 vs 4

3 vs 4

p value

p value

Subgroup 1

Subgroup 2

Subgroup 3

Subgroup 4

1 vs 2

1 vs 3

1 vs 4

2 vs 3

2 vs 4

3 vs 4

T-tau

NC

ADC: Innotest

240/73/13/4

0.428

28.4 ± 0.1

28 ± 0.2

27.3 ± 0.4

23.8 ± 0.9

6.45E−02

1.07E−02

2.00E−07

1.15E−01

2.20E−06

2.54E−04

1.14E−07

1.34E−05

0 ± 0.1

−0.2 ± 0.1 a

−0.3 ± 0.2

−2.2 ± 0.5 c

6.16E−02

1.51E−01

2.65E−06

7.06E−01

1.97E−05

8.86E−05

 

ADNI: Luminex

151/151/60/2

0.231

28.8 ± 0.1

28.8 ± 0.1

28.6 ± 0.1

29.3 ± 0.6

8.90E−01

1.07E−01

5.10E−01

7.92E−02

5.25E−01

3.06E−01

3.12E−01

3.23E−03

0 ± 0

−0.1 ± 0 b

− 0.3 ± 0 c

0.1 ± 0.3

1.38E−01

3.36E−04

5.15E−01

1.21E−02

3.55E−01

1.36E−01

 

ADNI: Elecsys

124/163/67/3

0.725

28.8 ± 0.1

28.8 ± 0.1

28.6 ± 0.1

28.7 ± 0.5

7.25E−01

1.58E−01

8.06E−01

2.20E−01

8.65E−01

8.82E−01

9.20E−02

1.15E−01

0 ± 0

−0.1 ± 0 b

−0.2 ± 0 c

0 ± 0.2

2.32E−01

1.60E−02

9.47E−01

1.20E−01

7.42E−01

4.69E−01

MCI

ADC: Innotest

199/170/92/4

0.270

26.6 ± 0.2

25 ± 0.2

24.2 ± 0.3

24.2 ± 1.7

7.98E−09

1.13E−11

1.47E−01

2.99E−02

6.39E−01

9.71E−01

2.05E−03

8.94E−13

−0.2 ± 0.1 a

−1.0 ± 0.1 c

− 1.3 ± 0.1 c

−0.6 ± 1

2.48E−10

3.78E−11

6.98E−01

1.35E−01

6.68E−01

5.13E−01

 

ADNI: Luminex

162/237/145/56

0.0002

27.9 ± 0.2

26.4 ± 0.2

25.1 ± 0.2

24 ± 0.4

1.36E−06

4.46E−16

4.12E−17

3.32E−05

3.80E−08

1.39E−02

1.74E−47

7.39E−17

−0.2 ± 0.1 a

−0.7 ± 0.1 c

−1.2 ± 0.1 c

− 1.6 ± 0.2 c

4.68E−05

3.56E−13

1.82E−14

7.80E−05

1.39E−07

1.69E−02

 

ADNI: Elecsys

145/247/154/41

0.0001

27.7 ± 0.2

26.7 ± 0.2

25.1 ± 0.2

23.7 ± 0.5

9.96E−04

2.04E−14

4.56E−14

1.12E−07

3.71E−09

9.62E−03

7.02E−43

7.36E−16

−0.2 ± 0.1 a

− 0.6 ± 0.1 c

−1.1 ± 0.1 c

− 1.8 ± 0.2 c

5.03E−04

2.90E−11

3.83E−14

6.21E−05

5.28E−09

9.50E−04

AD dementia

ADC: Innotest

122/303/280/38

0.172

20.4 ± 0.4

19.7 ± 0.3

18.9 ± 0.3

17.1 ± 0.8

1.58E−01

3.00E−03

1.58E−04

3.87E−02

1.32E−03

2.61E−02

1.72E−71

1.73E−04

−1.7 ± 0.2 c

−2.0 ± 0.1 c

−2.3 ± 0.1 c

− 3.5 ± 0.4 c

1.49E−01

1.55E−02

1.95E−05

2.00E−01

1.92E−04

1.69E−03

 

ADNI: Luminex

13/63/95/43

0.031

23.9 ± 0.9

22 ± 0.4

21.6 ± 0.3

20.8 ± 0.5

5.04E−02

1.41E−02

2.35E−03

4.16E−01

5.82E−02

1.77E−01

3.33E−16

1.29E−01

−1.5 ± 0.8 a

−2.0 ± 0.4 c

− 2.4 ± 0.3 c

− 3.2 ± 0.5 c

6.20E−01

3.06E−01

6.60E−02

3.67E−01

3.53E−02

1.34E−01

 

ADNI: Elecsys

13/68/99/28

0.008

25 ± 0.9

21.8 ± 0.4

21.3 ± 0.3

21.3 ± 0.6

1.00E−03

1.33E−04

6.41E−04

3.69E−01

4.77E−01

9.33E−01

8.53E−13

3.68E−02

−0.3 ± 0.8

−2.2 ± 0.4 c

− 2.4 ± 0.3 c

− 3.0 ± 0.6 c

2.48E−02

9.79E−03

4.88E−03

6.24E−01

2.33E−01

3.65E−01

P-tau

NC

ADC: Innotest

237/76/15/2

0.120

28.4 ± 0.1

28.2 ± 0.2

27.5 ± 0.4

22.2 ± 1

2.84E−01

2.48E−02

1.10E−08

1.03E−01

3.91E−08

3.65E−06

2.80E−07

3.36E−05

−0.1 ± 0.1

−0.1 ± 0.1

−0.2 ± 0.2

−2.5 ± 0.5 c

3.79E−01

4.50E−01

2.05E−06

7.62E−01

5.29E−06

2.55E−05

 

ADNI: Luminex

137/164/59/3

0.883

28.9 ± 0.1

28.7 ± 0.1

28.7 ± 0.1

29.1 ± 0.8

6.64E−02

1.13E−01

7.68E−01

7.89E−01

5.74E−01

5.43E−01

2.10E−01

1.35E−01

0 ± 0

−0.1 ± 0

−0.2 ± 0.1 b

−0.1 ± 0.4

5.87E−02

4.56E−02

8.32E−01

4.88E−01

9.82E−01

8.85E−01

 

ADNI: Elecsys

206/124/24/2

0.367

28.8 ± 0.1

28.7 ± 0.1

28.5 ± 0.2

29.2 ± 0.7

2.81E−01

1.70E−01

5.56E−01

4.27E−01

4.39E−01

3.15E−01

1.24E−01

8.11E−03

−1.3 ± 0.6 a

−2.1 ± 0.3 c

−2.7 ± 0.4 c

−3.0 ± 0.6 c

1.74E−01

3.60E−02

3.29E−02

2.52E−01

1.83E−01

5.96E−01

MCI

ADC: Innotest

208/173/79/5

0.575

26.3 ± 0.2

25.1 ± 0.2

24.3 ± 0.3

23.8 ± 1.4

6.13E−05

7.46E−08

7.69E−02

2.19E−02

3.41E−01

7.18E−01

2.94E−09

5.39E−08

−0.4 ± 0.1 c

−0.9 ± 0.1 c

−1.2 ± 0.1 c

−2.0 ± 0.7 b

1.32E−05

1.08E−07

2.23E−02

6.44E−02

1.32E−01

2.75E−01

 

ADNI: Luminex

164/259/161/12

0.009

27.7 ± 0.2

26.3 ± 0.2

25 ± 0.2

23.8 ± 0.8

1.03E−06

8.81E−17

8.02E−06

1.20E−05

4.47E−03

1.95E−01

2.19E−27

3.33E−16

−0.2 ± 0.1 a

−0.7 ± 0.1 c

−1.3 ± 0.1 c

−2.0 ± 0.3 c

1.04E−04

2.19E−16

3.76E−07

1.31E−07

1.50E−04

6.60E−02

 

ADNI: Elecsys

228/224/103/32

0.011

27.6 ± 0.2

26.1 ± 0.2

24.6 ± 0.3

23.7 ± 0.5

6.25E−08

3.34E−18

1.74E−12

8.99E−06

1.14E−05

1.32E−01

1.76E−46

5.50E−19

−0.2 ± 0.1 b

−0.8 ± 0.1 b

−1.4 ± 0.1 c

−1.8 ± 0.2 c

1.74E−01

3.60E−02

3.29E−02

2.52E−01

1.83E−01

5.96E−01

AD dementia

ADC: Innotest

149/348/216/30

0.250

20.2 ± 0.4

19.4 ± 0.2

19 ± 0.3

16.3 ± 0.9

7.19E−02

1.25E−02

4.35E−05

2.97E−01

6.82E−04

4.03E−03

2.75E−65

9.95E−05

−1.8 ± 0.2 c

−2 ± 0.1 c

−2.4 ± 0.1 c

−3.7 ± 0.4 c

3.14E−01

5.30E−03

7.50E−05

2.36E−02

2.48E−04

6.23E−03

 

ADNI: Luminex

17/98/83/14

0.483

23.7 ± 0.8

21.5 ± 0.3

21.5 ± 0.4

21.8 ± 0.9

1.21E−02

1.30E−02

1.20E−01

9.54E−01

7.47E−01

7.26E−01

1.62E−10

9.00E−02

−0.7 ± 0.7

−2.5 ± 0.3 c

−2.6 ± 0.3 c

−2.1 ± 0.8 a

2.00E−02

1.33E−02

2.06E−01

7.23E−01

6.68E−01

5.53E−01

 

ADNI: Elecsys

26/91/66/25

0.118

23.4 ± 0.7

21.8 ± 0.3

21.2 ± 0.4

21.2 ± 0.7

3.21E−02

4.37E−03

1.91E−02

2.39E−01

4.10E−01

9.88E−01

1.88E−18

9.79E−02

−1.3 ± 0.6 a

−2.1 ± 0.3 c

−2.7 ± 0.4 c

−3.0 ± 0.6 c

1.74E−01

3.60E−02

3.29E−02

2.52E−01

1.83E−01

5.96E−01

  1. All analyses were stratified for cognitive state and adjusted for age, sex and level of education. Slope that differs from 0 is indicated with a when p < .05, b when p < .01 or c when p < .001
  2. NC cognitively normal, MCI mild cognitive impairment, AD Alzheimer’s disease
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Alzheimer's Research & Therapy

ISSN: 1758-9193